{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu W"],"funding":["NIAID NIH HHS"],"pagination":["1010-22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3246047"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(6)"],"pubmed_abstract":["Activation of pattern recognition receptors on dendritic cells (DCs) and macrophages leads to secretion of cytokines that control differentiation of CD4(+) T cells. The current understanding is that interleukin-6 (IL-6) in combination with transforming growth factor-β (TGF-β) leads to generation of T helper 17 (Th17) lineage cells. Here, we have discovered that the cytokine requirements for Th17 cell polarization depend on the site of priming. Although IL-6 played a critical role in Th17 cell lineage priming in the skin and mucosal tissues, it was not required for Th17 cell priming in the spleen. In contrast, IL-1 played an irreplaceable role for priming of Th17 lineage cells in all tissues. Importantly, we have demonstrated that IL-6-independent and -dependent pathways of Th17 cell differ"],"journal":["Immunity"],"pubmed_title":["Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment."],"pmcid":["PMC3246047"],"funding_grant_id":["R01 AI082265","R01 AI082265-01A1","AI082265"],"pubmed_authors":["Pasare C","Edukulla R","Hu W","Troutman TD"],"additional_accession":[]},"is_claimable":false,"name":"Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment.","description":"Activation of pattern recognition receptors on dendritic cells (DCs) and macrophages leads to secretion of cytokines that control differentiation of CD4(+) T cells. The current understanding is that interleukin-6 (IL-6) in combination with transforming growth factor-β (TGF-β) leads to generation of T helper 17 (Th17) lineage cells. Here, we have discovered that the cytokine requirements for Th17 cell polarization depend on the site of priming. Although IL-6 played a critical role in Th17 cell lineage priming in the skin and mucosal tissues, it was not required for Th17 cell priming in the spleen. In contrast, IL-1 played an irreplaceable role for priming of Th17 lineage cells in all tissues. Importantly, we have demonstrated that IL-6-independent and -dependent pathways of Th17 cell differ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Dec","modification":"2025-04-22T04:56:25.04Z","creation":"2019-03-27T00:47:22Z"},"accession":"S-EPMC3246047","cross_references":{"pubmed":["22137454"],"doi":["10.1016/j.immuni.2011.10.013"]}}