biostudies-literatureSchoof NCancer Research UKWellcome Truste29451https://www.ebi.ac.uk/biostudies/studies/S-EPMC3246481biostudies-literatureUnknown6(12)Systemic immunosuppression is a risk factor for melanoma, and sunburn-induced immunosuppression is thought to be causal. Genes in immunosuppression pathways are therefore candidate melanoma-susceptibility genes. If variants within these genes individually have a small effect on disease risk, the association may be undetected in genome-wide association (GWA) studies due to low power to reach a high significance level. Pathway-based approaches have been suggested as a method of incorporating a priori knowledge into the analysis of GWA studies. In this study, the association of 1113 single nucleotide polymorphisms (SNPs) in 43 genes (39 genomic regions) related to immunosuppression have been analysed using a gene-set approach in 1539 melanoma cases and 3917 controls from the GenoMEL consortiuPloS onePathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression.PMC3246481C588/A10589C588/A499407611310589Newton-Bishop JARanderson-Moor JTaylor JCMing MTaylor YMartin NGRull RPurdie DGliori SDereure OGonzalez MPalou JVilalta ALeroux DGalore-Haskel GDoutre MSParsons PHansson JConill CVidal-Sicart SLundgren LSnels DNovakovic SLandi MTCasslen ASCaron OGruis NAGrange FBaeckenhorn KMalvehy JFaivre LMateus CBavinck JNKukutsch NPuig SMasback AKozlovaa EDugast CBadenas CJenkins MBerard FMarti-Laborda RNasti SGenomel Consortiumter Huurne JAzizi EWhiteman DHayward NKCaux FWebb PBishop JARonger-Savle SCuellar FLandi GMinghetti POlsson HKanetsky PGargiulo SMartin-Denavit TBonadona VLenoir GOlivier-Faivre LHocevar MBertazzi PALaitman YBattistuzzi LLipsker DVabres POrigone PScope AMacGregor SMack TBoitier FMartinez EHelsing Pde Lichy MAndry-Benzaquen PBachollet BLeake SAlos LKnorr JMolven ACambazard FBrochez LGhiorzo PNielsen KArcangeli FMontgomery GWvan der Stoep NMichel JLvan Nieuwpoort FADebniak TSchoof NSouteyrand PCarrera CStoppa-Lyonnet DVasen HHarland MCastel THaynes SQueirolo PKarpavicius BMann GJCrijns MChevrant-Breton JLubinski JSanchez MDuffy DMartin LMorel PHolland EAvan Praag MBerthet PChan MSassolas BKerob DHayward NBianchi-Scarra GCust AVilella RShimoni ILevang JArance AMaubec EDavies JVan Belle PMirecka AMila MArguis POut CPastorino LDemenais FAffleck PWhittaker LThomas LIles MMBonnetblanc JMBaron-Epel OButille JABekkenk MMilgrom ROgbah ZCampo AMansard SJeannin Pvan der Rhee HLang JLeccia MTErtmanski SElder DGabriel DBishop DTDalle SMohamdi HYakobson ELesueur FLasset CHoiom VMackie RJonsson GIngvar CChateigner NArmstrong BKCohen-Manheim IBarrett JHvan der Drift CAndresen PAIglesias PChompret AFriedman EBruno WRobert CChaudru VCalista DHumbert PKukalizch KWierzbicka EBressac-de Paillerets BCerkovnik PBergman WSchmid HGerritsen RKing PMitra NAitken JFAvril MFKefford RFGiles GGHarrison JRuffin AAguilera PBonafe JLCorda EDore MXDemange LPerrot JLBorg AHopper JLJoly PPavlotsky FRootwelt HPeric BBakker BAkslen LAfalsePathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression.Systemic immunosuppression is a risk factor for melanoma, and sunburn-induced immunosuppression is thought to be causal. Genes in immunosuppression pathways are therefore candidate melanoma-susceptibility genes. If variants within these genes individually have a small effect on disease risk, the association may be undetected in genome-wide association (GWA) studies due to low power to reach a high significance level. Pathway-based approaches have been suggested as a method of incorporating a priori knowledge into the analysis of GWA studies. In this study, the association of 1113 single nucleotide polymorphisms (SNPs) in 43 genes (39 genomic regions) related to immunosuppression have been analysed using a gene-set approach in 1539 melanoma cases and 3917 controls from the GenoMEL consortiu2011-01-01T00:00:00Z20112026-05-04T09:07:00.831Z2019-03-26T23:18:18ZS-EPMC32464812221628310.1371/journal.pone.0029451