{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ortiz S"],"funding":["NCI NIH HHS"],"pagination":["1450-63"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3247199"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["235(12)"],"pubmed_abstract":["Activation of T lymphoma cells expressing Syk, but not ZAP-70 tyrosine kinase, has been shown to negatively regulate cell activation and activation-induced cell death (AICD), perhaps due to differential induction of tyrosine phosphorylation modified proteins. To better understand the role of these proteins and their associated molecules/pathways, we studied a previously described model of T lymphoma cells expressing either a kinase-activated chimeric Syk or ZAP-70 genetically linked to T-cell receptor (TCR) ζ chain (Z/Syk or Z/ZAP cells, respectively). To help identify molecules and pathways linked to cell activation or AICD, a comparative semi-quantitative proteomics-based approach was utilized to analyze tyrosine-phosphorylated protein immunoprecipitates from two-minute short-term activa"],"journal":["Experimental biology and medicine (Maywood, N.J.)"],"pubmed_title":["Comparative analyses of differentially induced T-cell receptor-mediated phosphorylation pathways in T lymphoma cells."],"pmcid":["PMC3247199"],"funding_grant_id":["P50 CA107399","P30 CA033572","P30 CA33572","F31 CA117055"],"pubmed_authors":["Smith D","Liu CP","Lee TD","Ortiz S","Lee W","Forman SJ"],"additional_accession":[]},"is_claimable":false,"name":"Comparative analyses of differentially induced T-cell receptor-mediated phosphorylation pathways in T lymphoma cells.","description":"Activation of T lymphoma cells expressing Syk, but not ZAP-70 tyrosine kinase, has been shown to negatively regulate cell activation and activation-induced cell death (AICD), perhaps due to differential induction of tyrosine phosphorylation modified proteins. To better understand the role of these proteins and their associated molecules/pathways, we studied a previously described model of T lymphoma cells expressing either a kinase-activated chimeric Syk or ZAP-70 genetically linked to T-cell receptor (TCR) ζ chain (Z/Syk or Z/ZAP cells, respectively). To help identify molecules and pathways linked to cell activation or AICD, a comparative semi-quantitative proteomics-based approach was utilized to analyze tyrosine-phosphorylated protein immunoprecipitates from two-minute short-term activa","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Dec","modification":"2026-04-20T03:13:51.075Z","creation":"2026-04-20T03:10:03.847Z"},"accession":"S-EPMC3247199","cross_references":{"pubmed":["21127342"],"doi":["10.1258/ebm.2010.010056"]}}