{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang C"],"funding":["NCI NIH HHS"],"pagination":["o2948-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3247358"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["67(Pt 11)"],"pubmed_abstract":["THAILANDEPSIN A [SYSTEMATIC NAME: (E)-(1S,5S,6R,9S,20R)-6-[(2S)-butan-2-yl]-5-hy-droxy-20-[2-(meth-yl-sulfan-yl)eth-yl]-2-oxa-11,12-dithia-7,19,22-triaza-bicyclo-[7.7.6]docosa-15-ene-3,8,18,21-tetra-one], C(23)H(37)N(3)O(6)S(3), is a newly reported [Wang et al. (2011). J. Nat. Prod. doi:10.1021/np200324x] bicyclic depsipeptide that has potent histone deacetyl-ase inhibitory activity and broad-spectrum anti-proliferative activity. The absolute configuration of thailandepsin A has been determined from the anomalous dispersion and the stereochemistry of all chiral C atoms. Intra-molecular N-H⋯O and N-H⋯S hydrogen bonds occur. Inter-molecular N-H⋯O and O-H⋯O hydrogen bonds are observed in the crystal structure."],"journal":["Acta crystallographica. Section E, Structure reports online"],"pubmed_title":["Thailandepsin a."],"pmcid":["PMC3247358"],"funding_grant_id":["R01 CA152212"],"pubmed_authors":["Cheng YQ","Wang C"],"additional_accession":[]},"is_claimable":false,"name":"Thailandepsin a.","description":"THAILANDEPSIN A [SYSTEMATIC NAME: (E)-(1S,5S,6R,9S,20R)-6-[(2S)-butan-2-yl]-5-hy-droxy-20-[2-(meth-yl-sulfan-yl)eth-yl]-2-oxa-11,12-dithia-7,19,22-triaza-bicyclo-[7.7.6]docosa-15-ene-3,8,18,21-tetra-one], C(23)H(37)N(3)O(6)S(3), is a newly reported [Wang et al. (2011). J. Nat. Prod. doi:10.1021/np200324x] bicyclic depsipeptide that has potent histone deacetyl-ase inhibitory activity and broad-spectrum anti-proliferative activity. The absolute configuration of thailandepsin A has been determined from the anomalous dispersion and the stereochemistry of all chiral C atoms. Intra-molecular N-H⋯O and N-H⋯S hydrogen bonds occur. Inter-molecular N-H⋯O and O-H⋯O hydrogen bonds are observed in the crystal structure.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Nov","modification":"2024-12-04T11:55:02.15Z","creation":"2019-03-26T23:59:35Z"},"accession":"S-EPMC3247358","cross_references":{"pubmed":["22219976"],"doi":["10.1107/S1600536811041390"]}}