{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lamont BJ"],"funding":["CIHR"],"pagination":["388-402"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3248276"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(1)"],"pubmed_abstract":["Glucagon-like peptide-1 (GLP-1) circulates at low levels and acts as an incretin hormone, potentiating glucose-dependent insulin secretion from islet β cells. GLP-1 also modulates gastric emptying and engages neural circuits in the portal region and CNS that contribute to GLP-1 receptor-dependent (GLP-1R-dependent) regulation of glucose homeostasis. To elucidate the importance of pancreatic GLP-1R signaling for glucose homeostasis, we generated transgenic mice that expressed the human GLP-1R in islets and pancreatic ductal cells (Pdx1-hGLP1R:Glp1r-/- mice). Transgene expression restored GLP-1R-dependent stimulation of cAMP and Akt phosphorylation in isolated islets, conferred GLP-1R-dependent stimulation of β cell proliferation, and was sufficient for restoration of GLP-1-stimulated insuli"],"journal":["The Journal of clinical investigation"],"pubmed_title":["Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice."],"pmcid":["PMC3248276"],"funding_grant_id":["82700","MOP 82700","MOP 86544"],"pubmed_authors":["Li Y","Drucker DJ","Gaisano H","Kwan E","Lamont BJ","Brown TJ"],"additional_accession":[]},"is_claimable":false,"name":"Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice.","description":"Glucagon-like peptide-1 (GLP-1) circulates at low levels and acts as an incretin hormone, potentiating glucose-dependent insulin secretion from islet β cells. GLP-1 also modulates gastric emptying and engages neural circuits in the portal region and CNS that contribute to GLP-1 receptor-dependent (GLP-1R-dependent) regulation of glucose homeostasis. To elucidate the importance of pancreatic GLP-1R signaling for glucose homeostasis, we generated transgenic mice that expressed the human GLP-1R in islets and pancreatic ductal cells (Pdx1-hGLP1R:Glp1r-/- mice). Transgene expression restored GLP-1R-dependent stimulation of cAMP and Akt phosphorylation in isolated islets, conferred GLP-1R-dependent stimulation of β cell proliferation, and was sufficient for restoration of GLP-1-stimulated insuli","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jan","modification":"2025-04-19T04:19:49.272Z","creation":"2019-03-27T00:47:27Z"},"accession":"S-EPMC3248276","cross_references":{"pubmed":["22182839"],"doi":["10.1172/jci42497","10.1172/JCI42497"]}}