{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Panigrahy D"],"funding":["Intramural NIH HHS","NIEHS NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["178-91"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3248288"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(1)"],"pubmed_abstract":["Epoxyeicosatrienoic acids (EETs) are small molecules produced by cytochrome P450 epoxygenases. They are lipid mediators that act as autocrine or paracrine factors to regulate inflammation and vascular tone. As a result, drugs that raise EET levels are in clinical trials for the treatment of hypertension and many other diseases. However, despite their pleiotropic effects on cells, little is known about the role of these epoxyeicosanoids in cancer. Here, using genetic and pharmacological manipulation of endogenous EET levels, we demonstrate that EETs are critical for primary tumor growth and metastasis in a variety of mouse models of cancer. Remarkably, we found that EETs stimulated extensive multiorgan metastasis and escape from tumor dormancy in several tumor models. This systemic metastas"],"journal":["The Journal of clinical investigation"],"pubmed_title":["Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice."],"pmcid":["PMC3248288"],"funding_grant_id":["R01 ES002710","R01 CA148633","R01 GM088199","CA045548","P01 CA045548","R01 CA177875","Z01 ES050167","R01CA148633-01A1","P42 ES004699","Z01 ES025034","R01 ES013933","R00 CA140708"],"pubmed_authors":["Manthati VL","Tomer KB","Kaipainen A","Greene ER","Mammoto T","Pietramaggiori G","Lee CR","Schwendener RA","Falck JR","Ingber DE","Bielenberg DR","Zeldin DC","Benny O","Scherer-Pietramaggiori SS","Barnes CM","Luria A","D'Amore PA","Yang J","Butterfield CE","Chaponis DM","Dudley AC","Hammock BD","Short SM","Huang S","Seth M","Mammoto A","Lih FB","Edin ML","Kieran MW","Panigrahy D","Vergilio JA"],"additional_accession":[]},"is_claimable":false,"name":"Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice.","description":"Epoxyeicosatrienoic acids (EETs) are small molecules produced by cytochrome P450 epoxygenases. They are lipid mediators that act as autocrine or paracrine factors to regulate inflammation and vascular tone. As a result, drugs that raise EET levels are in clinical trials for the treatment of hypertension and many other diseases. However, despite their pleiotropic effects on cells, little is known about the role of these epoxyeicosanoids in cancer. Here, using genetic and pharmacological manipulation of endogenous EET levels, we demonstrate that EETs are critical for primary tumor growth and metastasis in a variety of mouse models of cancer. Remarkably, we found that EETs stimulated extensive multiorgan metastasis and escape from tumor dormancy in several tumor models. This systemic metastas","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jan","modification":"2026-04-16T09:04:25.263Z","creation":"2019-03-27T00:47:28Z"},"accession":"S-EPMC3248288","cross_references":{"pubmed":["22182838"],"doi":["10.1172/JCI58128","10.1172/jci58128"]}}