biostudies-literatureZhan WNCI NIH HHS1565-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC3249659biostudies-literatureUnknown10(8)A conformationally restrained epothilone A analogue (3) with a short bridge between methyl groups at C6 and C8 was designed and synthesized. Preliminary biological evaluation indicates 3 to be only weakly active (IC50 = 8.5 microM) against the A2780 human ovarian cancer cell line.Organic lettersDesign and synthesis of C6-C8 bridged epothilone A.PMC3249659R01 CA069571R01 CA069571-13CA 69571R01 CA069571-12Jiang YBrodie PJKingston DGLiotta DCSnyder JPZhan WfalseDesign and synthesis of C6-C8 bridged epothilone A.A conformationally restrained epothilone A analogue (3) with a short bridge between methyl groups at C6 and C8 was designed and synthesized. Preliminary biological evaluation indicates 3 to be only weakly active (IC50 = 8.5 microM) against the A2780 human ovarian cancer cell line.2008-01-01T00:00:00Z2008 Apr2025-04-19T13:48:55.218Z2019-03-27T00:47:33ZS-EPMC32496591835507610.1021/ol800422q