{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["283(36)"],"submitter":["Munirajan AK"],"pubmed_abstract":["Deletion of the distal region of chromosome 1 frequently occurs in a variety of human cancers, including aggressive neuroblastoma. Previously, we have identified a 500-kb homozygously deleted region at chromosome 1p36.2 harboring at least six genes in a neuroblastoma-derived cell line NB1/C201. Among them, only KIF1Bbeta, a member of the kinesin superfamily proteins, induced apoptotic cell death. These results prompted us to address whether KIF1Bbeta could be a tumor suppressor gene mapped to chromosome 1p36 in neuroblastoma. Hemizygous deletion of KIF1Bbeta in primary neuroblastomas was significantly correlated with advanced stages (p = 0.0013) and MYCN amplification (p < 0.001), whereas the mutation rate of the KIF1Bbeta gene was infrequent. Although KIF1Bbeta allelic loss was significan"],"journal":["The Journal of biological chemistry"],"pagination":["24426-34"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3259808"],"repository":["biostudies-literature"],"pubmed_title":["KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death."],"pmcid":["PMC3259808"],"pubmed_authors":["Suenaga Y","Hirota T","Koda T","Mukai A","Munirajan AK","Nakagawara A","Ando K","Takahashi M","Ozaki T","Ohira M"],"additional_accession":[]},"is_claimable":false,"name":"KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death.","description":"Deletion of the distal region of chromosome 1 frequently occurs in a variety of human cancers, including aggressive neuroblastoma. Previously, we have identified a 500-kb homozygously deleted region at chromosome 1p36.2 harboring at least six genes in a neuroblastoma-derived cell line NB1/C201. Among them, only KIF1Bbeta, a member of the kinesin superfamily proteins, induced apoptotic cell death. These results prompted us to address whether KIF1Bbeta could be a tumor suppressor gene mapped to chromosome 1p36 in neuroblastoma. Hemizygous deletion of KIF1Bbeta in primary neuroblastomas was significantly correlated with advanced stages (p = 0.0013) and MYCN amplification (p < 0.001), whereas the mutation rate of the KIF1Bbeta gene was infrequent. Although KIF1Bbeta allelic loss was significan","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Sep","modification":"2026-04-30T05:01:04.315Z","creation":"2019-03-27T00:48:02Z"},"accession":"S-EPMC3259808","cross_references":{"pubmed":["18614535"],"doi":["10.1074/jbc.m802316200","10.1074/jbc.M802316200"]}}