{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bhan U"],"funding":["NHLBI NIH HHS","National Institutes of Health"],"pagination":["2779-87"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3260863"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["179(6)"],"pubmed_abstract":["Hypersensitivity pneumonitis (HP), an inflammatory lung disease, develops after repeated exposure to inhaled particulate antigen and is characterized by a vigorous T helper type 1-mediated immune response, resulting in the release of IL-12 and interferon (IFN)-γ. These T helper type 1 cytokines may participate in the pathogenesis of HP. Stachybotrys chartarum (SC) is a dimorphic fungus implicated in a number of respiratory illnesses, including HP. Here, we have developed a murine model of SC-induced HP that reproduces pathology observed in human HP and hypothesized that toll receptor-like 9 (TLR9)-mediated dendritic cell responses are required for the generation of granulomatous inflammation induced by inhaled SC. Mice sensitized and challenged with 10(6) SC spores develop granulomatous in"],"journal":["The American journal of pathology"],"pubmed_title":["Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent."],"pmcid":["PMC3260863"],"funding_grant_id":["R01 HL057243","R01 HL25243","K08 HL094762","R01 HL097564","K08HL094762"],"pubmed_authors":["Newstead MJ","Standiford LR","Standiford TJ","Zeng X","Bhan U","Ballinger MN"],"additional_accession":[]},"is_claimable":false,"name":"Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent.","description":"Hypersensitivity pneumonitis (HP), an inflammatory lung disease, develops after repeated exposure to inhaled particulate antigen and is characterized by a vigorous T helper type 1-mediated immune response, resulting in the release of IL-12 and interferon (IFN)-γ. These T helper type 1 cytokines may participate in the pathogenesis of HP. Stachybotrys chartarum (SC) is a dimorphic fungus implicated in a number of respiratory illnesses, including HP. Here, we have developed a murine model of SC-induced HP that reproduces pathology observed in human HP and hypothesized that toll receptor-like 9 (TLR9)-mediated dendritic cell responses are required for the generation of granulomatous inflammation induced by inhaled SC. Mice sensitized and challenged with 10(6) SC spores develop granulomatous in","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Dec","modification":"2025-04-26T16:50:09.485Z","creation":"2019-03-27T00:48:07Z"},"accession":"S-EPMC3260863","cross_references":{"pubmed":["21982832"],"doi":["10.1016/j.ajpath.2011.08.019"]}}