{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liao YH"],"funding":["National Basic Research Program of China","NHLBI NIH HHS","National Natural Science Foundation of China","National Institutes of Health"],"pagination":["420-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3262985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["59(4)"],"pubmed_abstract":["<h4>Objectives</h4>This study tested whether interleukin (IL)-17A is involved in the pathogenesis of mouse myocardial ischemia/reperfusion (I/R) injury and investigated the mechanisms.<h4>Background</h4>Inflammatory processes play a major role in myocardial I/R injury. We recently identified IL-17A as an important cytokine in inflammatory cardiovascular diseases such as atherosclerosis and viral myocarditis. However, its role in myocardial I/R injury remains unknown.<h4>Methods</h4>The involvement of IL-17A was assessed in functional assays in mouse myocardial I/R injury by neutralization/repletion or genetic deficiency of IL-17A, and its mechanism on cardiomyocyte apoptosis and neutrophil infiltration were further studied in vivo and in vitro.<h4>Results</h4>Interleukin-17A was elevated a"],"journal":["Journal of the American College of Cardiology"],"pubmed_title":["Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration."],"pmcid":["PMC3262985"],"funding_grant_id":["R01 HL081090-04","R01 HL088547","HL88547","R01 HL060942","HL81090","30871067","R01 HL081090","HL60942","R01 HL088547-04","81170303","R01 HL060942-13"],"pubmed_authors":["Jevallee H","Zhou SF","Wang J","Iwakura Y","Cheng X","Yuan J","Yan XX","Liao YH","Tang TT","Xia N","Xiao H","Wei F","Nie SF","Shi GP","Lv BJ"],"additional_accession":[]},"is_claimable":false,"name":"Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration.","description":"<h4>Objectives</h4>This study tested whether interleukin (IL)-17A is involved in the pathogenesis of mouse myocardial ischemia/reperfusion (I/R) injury and investigated the mechanisms.<h4>Background</h4>Inflammatory processes play a major role in myocardial I/R injury. We recently identified IL-17A as an important cytokine in inflammatory cardiovascular diseases such as atherosclerosis and viral myocarditis. However, its role in myocardial I/R injury remains unknown.<h4>Methods</h4>The involvement of IL-17A was assessed in functional assays in mouse myocardial I/R injury by neutralization/repletion or genetic deficiency of IL-17A, and its mechanism on cardiomyocyte apoptosis and neutrophil infiltration were further studied in vivo and in vitro.<h4>Results</h4>Interleukin-17A was elevated a","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jan","modification":"2025-04-05T13:10:39.878Z","creation":"2019-03-27T00:48:16Z"},"accession":"S-EPMC3262985","cross_references":{"pubmed":["22261166"],"doi":["10.1016/j.jacc.2011.10.863"]}}