biostudies-literatureLiao YHNational Basic Research Program of ChinaNHLBI NIH HHSNational Natural Science Foundation of ChinaNational Institutes of Health420-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC3262985biostudies-literatureUnknown59(4)<h4>Objectives</h4>This study tested whether interleukin (IL)-17A is involved in the pathogenesis of mouse myocardial ischemia/reperfusion (I/R) injury and investigated the mechanisms.<h4>Background</h4>Inflammatory processes play a major role in myocardial I/R injury. We recently identified IL-17A as an important cytokine in inflammatory cardiovascular diseases such as atherosclerosis and viral myocarditis. However, its role in myocardial I/R injury remains unknown.<h4>Methods</h4>The involvement of IL-17A was assessed in functional assays in mouse myocardial I/R injury by neutralization/repletion or genetic deficiency of IL-17A, and its mechanism on cardiomyocyte apoptosis and neutrophil infiltration were further studied in vivo and in vitro.<h4>Results</h4>Interleukin-17A was elevated aJournal of the American College of CardiologyInterleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration.PMC3262985R01 HL081090-04R01 HL088547HL88547R01 HL060942HL8109030871067R01 HL081090HL60942R01 HL088547-0481170303R01 HL060942-13Jevallee HZhou SFWang JIwakura YCheng XYuan JYan XXLiao YHTang TTXia NXiao HWei FNie SFShi GPLv BJfalseInterleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration.<h4>Objectives</h4>This study tested whether interleukin (IL)-17A is involved in the pathogenesis of mouse myocardial ischemia/reperfusion (I/R) injury and investigated the mechanisms.<h4>Background</h4>Inflammatory processes play a major role in myocardial I/R injury. We recently identified IL-17A as an important cytokine in inflammatory cardiovascular diseases such as atherosclerosis and viral myocarditis. However, its role in myocardial I/R injury remains unknown.<h4>Methods</h4>The involvement of IL-17A was assessed in functional assays in mouse myocardial I/R injury by neutralization/repletion or genetic deficiency of IL-17A, and its mechanism on cardiomyocyte apoptosis and neutrophil infiltration were further studied in vivo and in vitro.<h4>Results</h4>Interleukin-17A was elevated a2012-01-01T00:00:00Z2012 Jan2025-04-05T13:10:39.878Z2019-03-27T00:48:16ZS-EPMC32629852226116610.1016/j.jacc.2011.10.863