biostudies-literatureUnknown50(2)Yebra GHIV-1 group M is classified into 9 subtypes, as well as recombinants favored by coinfection and superinfection events with different variants. Although HIV-1 subtype B is predominant in Europe, intersubtype recombinants are increasing in prevalence and complexity. In this study, phylogenetic analyses of pol sequences were performed to detect the HIV-1 circulating and unique recombinant forms (CRFs and URFs, respectively) in a Spanish cohort of antiretroviral treatment-naïve HIV-infected patients included in the Research Network on HIV/AIDS (CoRIS). Bootscanning and other methods were used to define complex recombinants not assigned to any subtype or CRF. A total of 670 available HIV-1 pol sequences from different patients were collected, of which 588 (87.8%) were assigned to HIV-1 subtype Journal of clinical microbiology407-13https://www.ebi.ac.uk/biostudies/studies/S-EPMC3264155biostudies-literatureMost HIV type 1 non-B infections in the Spanish cohort of antiretroviral treatment-naive HIV-infected patients (CoRIS) are due to recombinant viruses.PMC3264155Gadea Pastor CMontes Ramirez MLAzkune Galparsoro HDronda FLigero CCastro JMde los Santos IAntela AAguilar ACastiello JArraiza MJCervantes MPascual Pareja JFArrizabalaga JGutierrez CGutierrez FPortilla Tamarit ISanz Sanz JSola Boneta JAsensi VViciana PSegura FVeloso SBlanes Julia MRamirez Schacke MRiera MViciana IMunoz Perez APeraire JSanjuan MRubio RGiner Oncina LPrieto AAleman Valls MRPerez Valero IMoreno AMasia MMuga RMontolio FBoix Martinez VSalavert MLopez DMunoz-Fernandez MAArribas Lopez JRViciana Ramos ICohort of the Spanish AIDS Research Network (CoRIS)Losada ECuellar SManzardo CRobledano Garcia CPinilla Moraza JMurillas JAparicio ASRamos JMMoreno STrastoy MCamino XGarcia Torre APerez-Martinez LJordano Montanez QAngeles Munoz MBlanco JLGonzalez Garcia JPulido FGomez Sirvent JLPerez-Cachafeiro SFiorante SRuiz LSobrino Vegas PAramburu MJdel Valle JAleman MRIribarren JAHernandez BGomez-Mateos JPalacios Munoz RGarcia MSirvent JJParra Ruiz Jdel Amo JReus Banuls SCastanares CGarcia PDalmau DGarcia FPumares MCano Sanchez AMartinez EVelli PGomez Rico CLopez Lirola AMMetola LRecio Sanchez EMora Rillo MLopez-Dupla MPadilla SLeyes MLacruz Rodrigo JMatarranz MLopez Aldeguer JNavarro GLopez-Cortes LFBlanco FMunoz Medina LGallego de la Fuente JPerez ICarton JAMontero MIbanez LUriz JValle EHernandez Quero JNavarro APeral YMarti PGarcia-Alcaide FReparaz JAlvarez DMarquez Solero MQaneta RAPenaranda MGutierrez Cuellar IRivas PMiranda CSala MBlanco JRArribas BCaro-Murillo AMAmengual MJLozano de Leon FGarcia-Merino IMartin LGarcia Garcia FCosin Ochaita JCarrio Montiel JCHernandez Hernandez MIFont RPuerta Lopez TLabarga PLlenas JVillalonga CMacias JMiro JMRodriguez Martin CVidal FClotet Bvon Wichmann MAPineda VHolguin Ade Diego MMozas DOteo JASanz MBerenguer JJaen Manzanera Ade Mulder MRodriguez-Arrondo FAlonso Socas Mdel MTural CVargas MAlejos Ferreras BBernardino de la Serna IArcaina Toledo PBarreiro PTor JAngels Ribas MPadilla Ortega BBernal Morell ERuiz ADiaz-Flores FSarria Cepeda CXercavins Valls MOlona MZamora Vargas FJIbarra VIrigoyen Puig DPineda JAPerez Elias MJVilades CPascual Tome LMiralles PSoriano ARodriguez Fortunez PMartinez-Lacasa JSanvisens AYebra GHernando Sebastian VPena Monje ALopez Bernaldo de Quiros JCdel Romero Guerrero JCairo Llobell MMallolas JGatell JMBustinduy MJRodriguez JRodriguez CCasado JLPena Sanchez de Rivera JMCampins ASoriano VSantos Gonzalez JLopez-Dieguez MRodriguez VLeal MPenelo EMata RGoenaga MAMerino de Lucas EZamora LSanchez Conde MCalabuig EIrigoyen CPortilla Sogorb JfalseMost HIV type 1 non-B infections in the Spanish cohort of antiretroviral treatment-naive HIV-infected patients (CoRIS) are due to recombinant viruses.HIV-1 group M is classified into 9 subtypes, as well as recombinants favored by coinfection and superinfection events with different variants. Although HIV-1 subtype B is predominant in Europe, intersubtype recombinants are increasing in prevalence and complexity. In this study, phylogenetic analyses of pol sequences were performed to detect the HIV-1 circulating and unique recombinant forms (CRFs and URFs, respectively) in a Spanish cohort of antiretroviral treatment-naïve HIV-infected patients included in the Research Network on HIV/AIDS (CoRIS). Bootscanning and other methods were used to define complex recombinants not assigned to any subtype or CRF. A total of 670 available HIV-1 pol sequences from different patients were collected, of which 588 (87.8%) were assigned to HIV-1 subtype 2012-01-01T00:00:00Z2012 Feb2025-05-29T22:26:37.541Z2025-05-29T22:26:37.541ZS-EPMC32641552216255210.1128/JCM.05798-1110.1128/jcm.05798-11