{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Weickert MO"],"pubmed_abstract":["Background
Diets high in cereal-fiber (HCF) have been shown to improve whole-body insulin sensitivity. In search for potential mechanisms we hypothesized that a supplemented HCF-diet influences the composition of the human gut microbiota and/or biomarkers of colonic carbohydrate fermentation.Methods
We performed a randomized controlled 18-week intervention in group-matched overweight participants. Fecal samples of 69 participants receiving isoenergetic HCF (cereal-fiber 43 g/day), or control (cereal-fiber 14 g/day), or high-protein (HP, 28% of energy-intake, cereal-fiber 14 g/day), or moderately high cereal fiber/protein diets (MIX; protein 23% of energy-intake, cereal-fiber 26 g/day) with comparable fat contents were investigated for diet-induced changes of dominant groups"],"journal":["Nutrition & metabolism"],"pagination":["90"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3264513"],"repository":["biostudies-literature"],"pubmed_title":["Changes in dominant groups of the gut microbiota do not explain cereal-fiber induced improvement of whole-body insulin sensitivity."],"pmcid":["PMC3264513"],"pubmed_authors":["Becker N","Alpert C","Weickert MO","Blaut M","Mohlig M","Rudovich N","Pfeiffer AF","Arafat AM","Leupelt V"],"additional_accession":[]},"is_claimable":false,"name":"Changes in dominant groups of the gut microbiota do not explain cereal-fiber induced improvement of whole-body insulin sensitivity.","description":"Background
Diets high in cereal-fiber (HCF) have been shown to improve whole-body insulin sensitivity. In search for potential mechanisms we hypothesized that a supplemented HCF-diet influences the composition of the human gut microbiota and/or biomarkers of colonic carbohydrate fermentation.Methods
We performed a randomized controlled 18-week intervention in group-matched overweight participants. Fecal samples of 69 participants receiving isoenergetic HCF (cereal-fiber 43 g/day), or control (cereal-fiber 14 g/day), or high-protein (HP, 28% of energy-intake, cereal-fiber 14 g/day), or moderately high cereal fiber/protein diets (MIX; protein 23% of energy-intake, cereal-fiber 26 g/day) with comparable fat contents were investigated for diet-induced changes of dominant groups","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Dec","modification":"2026-04-07T18:03:05.994Z","creation":"2025-06-26T03:06:53.695Z"},"accession":"S-EPMC3264513","cross_references":{"pubmed":["22177085"],"doi":["10.1186/1743-7075-8-90"]}}