biostudies-literatureUnknown8Weickert MO<h4>Background</h4>Diets high in cereal-fiber (HCF) have been shown to improve whole-body insulin sensitivity. In search for potential mechanisms we hypothesized that a supplemented HCF-diet influences the composition of the human gut microbiota and/or biomarkers of colonic carbohydrate fermentation.<h4>Methods</h4>We performed a randomized controlled 18-week intervention in group-matched overweight participants. Fecal samples of 69 participants receiving isoenergetic HCF (cereal-fiber 43 g/day), or control (cereal-fiber 14 g/day), or high-protein (HP, 28% of energy-intake, cereal-fiber 14 g/day), or moderately high cereal fiber/protein diets (MIX; protein 23% of energy-intake, cereal-fiber 26 g/day) with comparable fat contents were investigated for diet-induced changes of dominant groupsNutrition & metabolism90https://www.ebi.ac.uk/biostudies/studies/S-EPMC3264513biostudies-literatureChanges in dominant groups of the gut microbiota do not explain cereal-fiber induced improvement of whole-body insulin sensitivity.PMC3264513Becker NAlpert CWeickert MOBlaut MMohlig MRudovich NPfeiffer AFArafat AMLeupelt VfalseChanges in dominant groups of the gut microbiota do not explain cereal-fiber induced improvement of whole-body insulin sensitivity.<h4>Background</h4>Diets high in cereal-fiber (HCF) have been shown to improve whole-body insulin sensitivity. In search for potential mechanisms we hypothesized that a supplemented HCF-diet influences the composition of the human gut microbiota and/or biomarkers of colonic carbohydrate fermentation.<h4>Methods</h4>We performed a randomized controlled 18-week intervention in group-matched overweight participants. Fecal samples of 69 participants receiving isoenergetic HCF (cereal-fiber 43 g/day), or control (cereal-fiber 14 g/day), or high-protein (HP, 28% of energy-intake, cereal-fiber 14 g/day), or moderately high cereal fiber/protein diets (MIX; protein 23% of energy-intake, cereal-fiber 26 g/day) with comparable fat contents were investigated for diet-induced changes of dominant groups2011-01-01T00:00:00Z2011 Dec2026-04-07T18:03:05.994Z2025-06-26T03:06:53.695ZS-EPMC32645132217708510.1186/1743-7075-8-90