{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["101(4)"],"submitter":["Toyama-Sorimachi N"],"pubmed_abstract":["Here, we identified and characterized a Ly49 family member, designated as Ly49Q. The Ly49q gene encodes a 273-aa protein with an immunoreceptor tyrosine-based inhibitory motif (ITIM) at the N terminus of its cytoplasmic domain. We show that the ITIM of Ly49Q can recruit SHP-2 and SHP-1 in a tyrosine phosphorylation-dependent manner. In contrast to other known members of the Ly49 family, Ly49Q was found not to be expressed on NK1.1(+) cells, but instead was detectable on virtually all Gr-1(+) cells, such as myeloid precursors in bone marrow. Monocytes/macrophages also expressed low levels of Ly49Q, and the expression was enhanced by the treatment of cells with IFN-gamma. Treatment of activated macrophages with anti-Ly49Q mAb induced rapid formation of polarized actin structures, showing fil"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["1016-21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC327143"],"repository":["biostudies-literature"],"pubmed_title":["Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture."],"pmcid":["PMC327143"],"pubmed_authors":["Karasuyama H","Onoda A","Koyasu S","Maruya M","Tsujimura Y","Kubota T","Inaba K","Toyama-Sorimachi N"],"additional_accession":[]},"is_claimable":false,"name":"Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture.","description":"Here, we identified and characterized a Ly49 family member, designated as Ly49Q. The Ly49q gene encodes a 273-aa protein with an immunoreceptor tyrosine-based inhibitory motif (ITIM) at the N terminus of its cytoplasmic domain. We show that the ITIM of Ly49Q can recruit SHP-2 and SHP-1 in a tyrosine phosphorylation-dependent manner. In contrast to other known members of the Ly49 family, Ly49Q was found not to be expressed on NK1.1(+) cells, but instead was detectable on virtually all Gr-1(+) cells, such as myeloid precursors in bone marrow. Monocytes/macrophages also expressed low levels of Ly49Q, and the expression was enhanced by the treatment of cells with IFN-gamma. Treatment of activated macrophages with anti-Ly49Q mAb induced rapid formation of polarized actin structures, showing fil","dates":{"release":"2004-01-01T00:00:00Z","publication":"2004 Jan","modification":"2025-04-05T15:44:42.444Z","creation":"2019-03-27T00:50:01Z"},"accession":"S-EPMC327143","cross_references":{"pubmed":["14732700"],"doi":["10.1073/pnas.0305400101"]}}