biostudies-literatureUnknown12Ali R<h4>Background</h4>High quality evidence indicates that aspirin is effective in reducing colorectal polyps; and numerous epidemiological studies point towards an ability to prevent colorectal cancer. However the role of Aspirin as an adjuvant agent in patients with established cancers remains to be defined. Recently a nested case-control study within the Nurses Health cohort suggested that the initiation of Aspirin after the diagnosis of colon cancer reduced overall colorectal cancer specific mortality. Although this data is supportive of Aspirin's biological activity in this disease and possible role in adjuvant therapy, it needs to be confirmed in a randomized prospective trial.<h4>Methods/design</h4>We hypothesize through this randomized, placebo-controlled adjuvant study, that Aspirin Trials261https://www.ebi.ac.uk/biostudies/studies/S-EPMC3271983biostudies-literatureThe utility of Aspirin in Dukes C and High Risk Dukes B Colorectal cancer--the ASCOLT study: study protocol for a randomized controlled trial.PMC3271983Chang TCChucheep SSivanesan BChang CSKhong RRinaldi IPrajogi GBLaw WLChao TYChansilpa YKu GChen HCTantiplachiva KLopes GMellinas LLai GMMallath MChoo SPWei PLLow JJian XTham CKMastura BMASCOLT Trial InvestigatorsKurnianda JLiu JHDankulchai PJuo LJHo GFYau TDasappa LChang AWidayati KAbdullah MJirawat PABasir INoorwati SDeng YHPurwanto ILim HYToh HCSoemardi AAndalusia RHsieh YYChou CMDeniel ASajeed AWang CCLee JCBae AJHsieh CIHuang SYSharma ALo SKSacdalan DLGanesan TSWang WHuang KCParreno DMaengkom FAkewanlop CSyafei STan ILim KHChen CMNathan ETan DLin PCChen CCAkaraviputh TChen CHKullathorn TRajkumar ASu YWRaj TATeng HWIsmail AShin SJHuang IPLin BWChacko RTLin TCAtittharnsakul PAzrif MChia WKHua CYen CCLin SYRoslani ACBharwani LSim RKoo WHSu WCRoh JKLin JTLin SCAli RChopra ASadashivudu GChung CYOng SLau FLin JKHsu SZfalseThe utility of Aspirin in Dukes C and High Risk Dukes B Colorectal cancer--the ASCOLT study: study protocol for a randomized controlled trial.<h4>Background</h4>High quality evidence indicates that aspirin is effective in reducing colorectal polyps; and numerous epidemiological studies point towards an ability to prevent colorectal cancer. However the role of Aspirin as an adjuvant agent in patients with established cancers remains to be defined. Recently a nested case-control study within the Nurses Health cohort suggested that the initiation of Aspirin after the diagnosis of colon cancer reduced overall colorectal cancer specific mortality. Although this data is supportive of Aspirin's biological activity in this disease and possible role in adjuvant therapy, it needs to be confirmed in a randomized prospective trial.<h4>Methods/design</h4>We hypothesize through this randomized, placebo-controlled adjuvant study, that Aspirin 2011-01-01T00:00:00Z2011 Dec2025-04-03T22:54:56.673Z2019-03-27T00:48:43ZS-EPMC32719832216856810.1186/1745-6215-12-261