{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu PT"],"funding":["NIAID NIH HHS","NIAMS NIH HHS"],"pagination":["267-73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3274599"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(2)"],"pubmed_abstract":["Leprosy provides a model to investigate mechanisms of immune regulation in humans, given that the disease forms a spectrum of clinical presentations that correlate with host immune responses. Here we identified 13 miRNAs that were differentially expressed in the lesions of subjects with progressive lepromatous (L-lep) versus the self-limited tuberculoid (T-lep) disease. Bioinformatic analysis revealed a significant enrichment of L-lep-specific miRNAs that preferentially target key immune genes downregulated in L-lep versus T-lep lesions. The most differentially expressed miRNA in L-lep lesions, hsa-mir-21, was upregulated in Mycobacterium leprae-infected monocytes. By directly downregulating Toll-like receptor 2/1 heterodimer (TLR2/1)-induced CYP27B1 and IL1B expression as well as indirect"],"journal":["Nature medicine"],"pubmed_title":["MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy."],"pmcid":["PMC3274599"],"funding_grant_id":["R01 AI022553","AI 073539","AI 047868","R01 AI082575","AR 040312","K22 AI085025","AI 022553","R37 AI047868","R01 AR040312","K22 AI 85025","R01 AI073539","R01 AI047868"],"pubmed_authors":["Vazirnia A","Liu PT","Sarno EN","Edfeldt K","Komisopoulou E","Modlin RL","Wheelwright M","Teles R","Mehta MD","Graeber TG","Ferguson B","Rea TH"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy.","description":"Leprosy provides a model to investigate mechanisms of immune regulation in humans, given that the disease forms a spectrum of clinical presentations that correlate with host immune responses. Here we identified 13 miRNAs that were differentially expressed in the lesions of subjects with progressive lepromatous (L-lep) versus the self-limited tuberculoid (T-lep) disease. Bioinformatic analysis revealed a significant enrichment of L-lep-specific miRNAs that preferentially target key immune genes downregulated in L-lep versus T-lep lesions. The most differentially expressed miRNA in L-lep lesions, hsa-mir-21, was upregulated in Mycobacterium leprae-infected monocytes. By directly downregulating Toll-like receptor 2/1 heterodimer (TLR2/1)-induced CYP27B1 and IL1B expression as well as indirect","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jan","modification":"2026-04-28T22:11:28.687Z","creation":"2026-04-07T14:42:31.341Z"},"accession":"S-EPMC3274599","cross_references":{"pubmed":["22286305"],"doi":["10.1038/nm.2584"]}}