{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Horning M"],"funding":["Core Research for Evolutional Science and Technology","Ministry of Education, Culture, Sports, Science and Technology","Japan Science and Technology Agency","Japan Society for the Promotion of Science"],"pagination":["379-87"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3274804"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["102(3)"],"pubmed_abstract":["Biomechanical dynamic interactions between cells and the extracellular environment dynamically regulate physiological tissue behavior in living organisms, such as that seen in tissue maintenance and remodeling. In this study, the substrate-induced modulation of synchronized beating in cultured cardiomyocyte tissue was systematically characterized on elasticity-tunable substrates to elucidate the effect of biomechanical coupling. We found that myocardial conduction is significantly promoted when the rigidity of the cell culture environment matches that of the cardiac cells (4 kiloPascals). The stability of spontaneous target wave activity and calcium transient alternans in high frequency-paced tissue were both enhanced when the cell substrate and cell tissue showed the same rigidity. By ada"],"journal":["Biophysical journal"],"pubmed_title":["Rigidity matching between cells and the extracellular matrix leads to the stabilization of cardiac conduction."],"pmcid":["PMC3274804"],"funding_grant_id":["23240044","21-102"],"pubmed_authors":["Kidoaki S","Horning M","Kawano T","Yoshikawa K"],"additional_accession":[]},"is_claimable":false,"name":"Rigidity matching between cells and the extracellular matrix leads to the stabilization of cardiac conduction.","description":"Biomechanical dynamic interactions between cells and the extracellular environment dynamically regulate physiological tissue behavior in living organisms, such as that seen in tissue maintenance and remodeling. In this study, the substrate-induced modulation of synchronized beating in cultured cardiomyocyte tissue was systematically characterized on elasticity-tunable substrates to elucidate the effect of biomechanical coupling. We found that myocardial conduction is significantly promoted when the rigidity of the cell culture environment matches that of the cardiac cells (4 kiloPascals). The stability of spontaneous target wave activity and calcium transient alternans in high frequency-paced tissue were both enhanced when the cell substrate and cell tissue showed the same rigidity. By ada","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Feb","modification":"2025-04-25T21:34:07.767Z","creation":"2019-03-27T00:48:54Z"},"accession":"S-EPMC3274804","cross_references":{"pubmed":["22325259"],"doi":["10.1016/j.bpj.2011.12.018"]}}