biostudies-literatureUnknown11Adamo GM<h4>Background</h4>Yeast strains endowed with robustness towards copper and/or enriched in intracellular Cu might find application in biotechnology processes, among others in the production of functional foods. Moreover, they can contribute to the study of human diseases related to impairments of copper metabolism. In this study, we investigated the molecular and physiological factors that confer copper tolerance to strains of baker's yeasts.<h4>Results</h4>We characterized the effects elicited in natural strains of Candida humilis and Saccharomyces cerevisiae by the exposure to copper in the culture broth. We observed that, whereas the growth of Saccharomyces cells was inhibited already at low Cu concentration, C. humilis was naturally robust and tolerated up to 1 g · L-1 CuSO4 in the medMicrobial cell factories1https://www.ebi.ac.uk/biostudies/studies/S-EPMC3276424biostudies-literatureLaboratory evolution of copper tolerant yeast strains.PMC3276424Adamo GMPassolunghi SBrocca SSalvato BLotti MfalseLaboratory evolution of copper tolerant yeast strains.<h4>Background</h4>Yeast strains endowed with robustness towards copper and/or enriched in intracellular Cu might find application in biotechnology processes, among others in the production of functional foods. Moreover, they can contribute to the study of human diseases related to impairments of copper metabolism. In this study, we investigated the molecular and physiological factors that confer copper tolerance to strains of baker's yeasts.<h4>Results</h4>We characterized the effects elicited in natural strains of Candida humilis and Saccharomyces cerevisiae by the exposure to copper in the culture broth. We observed that, whereas the growth of Saccharomyces cells was inhibited already at low Cu concentration, C. humilis was naturally robust and tolerated up to 1 g · L-1 CuSO4 in the med2012-01-01T00:00:00Z2012 Jan2025-04-26T07:39:12.677Z2019-03-27T00:48:58ZS-EPMC32764242221428610.1186/1475-2859-11-1