{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(2)"],"submitter":["El-Murr N"],"pubmed_abstract":["Mismatch repair-deficient colorectal cancers (CRC) display widespread instability at DNA microsatellite sequences (MSI). Although MSI has been reported to commonly occur at coding repeats, leading to alterations in the function of a number of genes encoding cancer-related proteins, nothing is known about the putative impact of this process on non-coding microRNAs. In miRbase V15, we identified very few human microRNA genes with mono- or di-nucleotide repeats (n = 27). A mutational analysis of these sequences in a large series of MSI CRC cell lines and primary tumors underscored instability in 15 of the 24 microRNA genes successfully studied at variable frequencies ranging from 2.5% to 100%. Following a maximum likelihood statistical method, microRNA genes were separated into two groups tha"],"journal":["PloS one"],"pagination":["e31862"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3279428"],"repository":["biostudies-literature"],"pubmed_title":["MiRNA genes constitute new targets for microsatellite instability in colorectal cancer."],"pmcid":["PMC3279428"],"pubmed_authors":["Abidi Z","Gaub MP","Lesuffleur T","Flejou JF","Hamelin R","El-Murr N","Wanherdrick K","Duval A","Svrcek M"],"additional_accession":[]},"is_claimable":false,"name":"MiRNA genes constitute new targets for microsatellite instability in colorectal cancer.","description":"Mismatch repair-deficient colorectal cancers (CRC) display widespread instability at DNA microsatellite sequences (MSI). Although MSI has been reported to commonly occur at coding repeats, leading to alterations in the function of a number of genes encoding cancer-related proteins, nothing is known about the putative impact of this process on non-coding microRNAs. In miRbase V15, we identified very few human microRNA genes with mono- or di-nucleotide repeats (n = 27). A mutational analysis of these sequences in a large series of MSI CRC cell lines and primary tumors underscored instability in 15 of the 24 microRNA genes successfully studied at variable frequencies ranging from 2.5% to 100%. Following a maximum likelihood statistical method, microRNA genes were separated into two groups tha","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2026-05-02T06:09:15.712Z","creation":"2026-04-07T17:41:49.678Z"},"accession":"S-EPMC3279428","cross_references":{"pubmed":["22348132"],"doi":["10.1371/journal.pone.0031862"]}}