{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2"],"submitter":["Shih CT"],"pubmed_abstract":["Electronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycosylases and the regulation of tumor-suppressor genes such as p53 by detection of oxidative damage. However, the reproducible measurement and modelling of charge migration through DNA molecules at the nanometer scale remains a challenging and controversial subject even after more than a decade of intense efforts. Here we show, by analysing 162 disease-related genes from a variety of medical databases with a total of almost 20,000 observed pathogenic mutations, a significant difference in the electronic properties of the population of observed mutations compared to the set of all possible mutations. Our results have"],"journal":["Scientific reports"],"pagination":["272"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3280594"],"repository":["biostudies-literature"],"pubmed_title":["The interplay of mutations and electronic properties in disease-related genes."],"pmcid":["PMC3280594"],"pubmed_authors":["Wells SA","Romer RA","Hsu CL","Shih CT","Cheng YY"],"additional_accession":[]},"is_claimable":false,"name":"The interplay of mutations and electronic properties in disease-related genes.","description":"Electronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycosylases and the regulation of tumor-suppressor genes such as p53 by detection of oxidative damage. However, the reproducible measurement and modelling of charge migration through DNA molecules at the nanometer scale remains a challenging and controversial subject even after more than a decade of intense efforts. Here we show, by analysing 162 disease-related genes from a variety of medical databases with a total of almost 20,000 observed pathogenic mutations, a significant difference in the electronic properties of the population of observed mutations compared to the set of all possible mutations. Our results have","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2025-04-18T14:00:15.922Z","creation":"2019-03-27T00:49:12Z"},"accession":"S-EPMC3280594","cross_references":{"pubmed":["22355784"],"doi":["10.1038/srep00272"]}}