biostudies-literatureUnknown2Shih CTElectronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycosylases and the regulation of tumor-suppressor genes such as p53 by detection of oxidative damage. However, the reproducible measurement and modelling of charge migration through DNA molecules at the nanometer scale remains a challenging and controversial subject even after more than a decade of intense efforts. Here we show, by analysing 162 disease-related genes from a variety of medical databases with a total of almost 20,000 observed pathogenic mutations, a significant difference in the electronic properties of the population of observed mutations compared to the set of all possible mutations. Our results haveScientific reports272https://www.ebi.ac.uk/biostudies/studies/S-EPMC3280594biostudies-literatureThe interplay of mutations and electronic properties in disease-related genes.PMC3280594Wells SARomer RAHsu CLShih CTCheng YYfalseThe interplay of mutations and electronic properties in disease-related genes.Electronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycosylases and the regulation of tumor-suppressor genes such as p53 by detection of oxidative damage. However, the reproducible measurement and modelling of charge migration through DNA molecules at the nanometer scale remains a challenging and controversial subject even after more than a decade of intense efforts. Here we show, by analysing 162 disease-related genes from a variety of medical databases with a total of almost 20,000 observed pathogenic mutations, a significant difference in the electronic properties of the population of observed mutations compared to the set of all possible mutations. Our results have2012-01-01T00:00:00Z20122025-04-18T14:00:15.922Z2019-03-27T00:49:12ZS-EPMC32805942235578410.1038/srep00272