{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["119(3)"],"submitter":["Kurz A"],"pubmed_abstract":["Parkinson's disease (PD) is a neurodegenerative disorder frequent at old age characterized by atrophy of the nigrostriatal projection. Overexpression and A53T-mutation of the presynaptic, vesicle-associated chaperone alpha-synuclein are known to cause early-onset autosomal dominant PD. We previously generated mice with transgenic overexpression of human A53T-alpha-synuclein (A53T-SNCA) in dopaminergic substantia nigra neurons as a model of early PD. To elucidate the early and late effects of A53T-alpha-synuclein on the proteome of dopaminergic nerve terminals in the striatum, we now investigated expression profiles of young and old mice using two-dimensional fluorescence difference in gel electrophoresis (2D-DIGE) and mass spectrometry. In total, 15 proteins were upregulated and 2 downregu"],"journal":["Journal of neural transmission (Vienna, Austria : 1996)"],"pagination":["297-312"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3282907"],"repository":["biostudies-literature"],"pubmed_title":["A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP."],"pmcid":["PMC3282907"],"pubmed_authors":["Schmidt O","Kurz A","May C","Meyer HE","Marcus K","Muller T","Auburger G","Gispert S","Stephan C"],"additional_accession":[]},"is_claimable":false,"name":"A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP.","description":"Parkinson's disease (PD) is a neurodegenerative disorder frequent at old age characterized by atrophy of the nigrostriatal projection. Overexpression and A53T-mutation of the presynaptic, vesicle-associated chaperone alpha-synuclein are known to cause early-onset autosomal dominant PD. We previously generated mice with transgenic overexpression of human A53T-alpha-synuclein (A53T-SNCA) in dopaminergic substantia nigra neurons as a model of early PD. To elucidate the early and late effects of A53T-alpha-synuclein on the proteome of dopaminergic nerve terminals in the striatum, we now investigated expression profiles of young and old mice using two-dimensional fluorescence difference in gel electrophoresis (2D-DIGE) and mass spectrometry. In total, 15 proteins were upregulated and 2 downregu","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2026-04-08T00:57:46.323Z","creation":"2026-04-07T20:00:28.447Z"},"accession":"S-EPMC3282907","cross_references":{"pubmed":["21960009"],"doi":["10.1007/s00702-011-0717-3"]}}