{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lu J"],"funding":["European Research Council","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["1454-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3285120"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["134(3)"],"pubmed_abstract":["Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to a high-affinity interdomain site that disrupts at least one Zn site. Albumin may be a molecular device to \"translate\" certain aspects of the organismal energy state into global zinc signals."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["A molecular mechanism for modulating plasma Zn speciation by fatty acids."],"pmcid":["PMC3285120"],"funding_grant_id":["247450","070481","BB/D524516/1","REI BB/D524516/1"],"pubmed_authors":["Blindauer CA","Sleep D","Stewart AJ","Pinheiro TJ","Lu J","Sadler PJ"],"additional_accession":[]},"is_claimable":false,"name":"A molecular mechanism for modulating plasma Zn speciation by fatty acids.","description":"Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to a high-affinity interdomain site that disrupts at least one Zn site. Albumin may be a molecular device to \"translate\" certain aspects of the organismal energy state into global zinc signals.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jan","modification":"2026-04-18T15:01:35.546Z","creation":"2019-03-27T00:49:22Z"},"accession":"S-EPMC3285120","cross_references":{"pubmed":["22239162"],"doi":["10.1021/ja210496n"]}}