{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["109(8)"],"submitter":["Bonnans C"],"pubmed_abstract":["β-Arrestins (Arrb) participate in the regulation of multiple signaling pathways, including Wnt/β-catenin, the major actor in human colorectal cancer initiation. To better understand the roles of Arrb in intestinal tumorigenesis, a reverse genetic approach (Arrb(-/-)) and in vivo siRNA treatment were used in Apc(Δ14/+) mice. Mice with Arrb2 depletion (knockout and siRNA) developed only 33% of the tumors detected in their Arrb2-WT littermates, whereas Arrb1 depletion remained without significant effect. These remaining tumors grow normally and are essentially Arrb2-independent. Unsupervised hierarchical clustering analysis showed that they clustered with 25% of Apc(Δ14/+);Arrb2(+/+) tumors. Genes overexpressed in this subset reflect a high interaction with the immune system, whereas those ov"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["3047-52"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3286958"],"repository":["biostudies-literature"],"pubmed_title":["Essential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signaling."],"pmcid":["PMC3286958"],"pubmed_authors":["Crespy P","Severac D","Desvignes JP","Bonnans C","Flaceliere M","Hollande F","Escriou V","Grillet F","Journot L","Dantec C","Bibeau F","Pannequin J","Joubert D","Dubois E"],"additional_accession":[]},"is_claimable":false,"name":"Essential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signaling.","description":"β-Arrestins (Arrb) participate in the regulation of multiple signaling pathways, including Wnt/β-catenin, the major actor in human colorectal cancer initiation. To better understand the roles of Arrb in intestinal tumorigenesis, a reverse genetic approach (Arrb(-/-)) and in vivo siRNA treatment were used in Apc(Δ14/+) mice. Mice with Arrb2 depletion (knockout and siRNA) developed only 33% of the tumors detected in their Arrb2-WT littermates, whereas Arrb1 depletion remained without significant effect. These remaining tumors grow normally and are essentially Arrb2-independent. Unsupervised hierarchical clustering analysis showed that they clustered with 25% of Apc(Δ14/+);Arrb2(+/+) tumors. Genes overexpressed in this subset reflect a high interaction with the immune system, whereas those ov","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Feb","modification":"2026-04-30T10:45:00.964Z","creation":"2026-04-07T15:59:28.054Z"},"accession":"S-EPMC3286958","cross_references":{"pubmed":["22315403"],"doi":["10.1073/pnas.1109457109"]}}