biostudies-literatureUnknown44(1)Hunt KAMedical Research CouncilNational Institute for Health Research (NIHR)Chief Scientist OfficeNIAMS NIH HHSWellcome TrustCrohn's and Colitis UKNature genetics3-5https://www.ebi.ac.uk/biostudies/studies/S-EPMC3287292biostudies-literatureRare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry.PMC3287292P01 AR048929G0800759NF-SI-0508-10335G1001158RC1 AR058587M11-1089120CZB/4/540077011091157G0800675ETM/75NF-SI-0508-10275090532P30 AR047363G0600329G0700545ETM/137Ludvigsson JNimmo ERStarkman HCouch RIlonen JKrikovszky DLane JHomatopoulos NPociot FCollado RCGunville FMathew CGPaterson ASoyka LMychaleckyj JPhillip MBingley PDunger DFear ALBabadjanova GRussell BWalker NRushing SRangantah VHeath SCaulfield MJBadenhoop KMetzger DRussell RBockett NAMarrosu MGHawkins SOlsem GYoung NYu LHill AVBhatia VPotter SRubalcava LBhatia SWilson DCOuwehand WVyse TJStratton MRQuattrin TTodd JRatnam NBrismar KBraden JKaur GSpeiser PHolzheu IZimmerman DYin LKNierras CBhatia EPrescott NJLiktimaskul SHermon OLee JCHamou AOkruszko AGriffin JPoh PSides EDavis TLacalle CGVazeo-Gerasimidi ABautista NGoldstein BZoledziewska MGoodwin GEike MCWorthington JPozzilli PSingle RBenoist CRokni SWagner AMayer-Davis BKahles HSambrook JNoble JMistry VMistry TShilling HPettinari CPodolsky RCastano LOrlowski CGreenbaum CSanderson JAgleham MBoyle SBarral SMraz GSing RPugliese AKwiatkowski DPHarrison KLWithers HHassing JWalker NMvan Diemen CCStevens HLipton RDowling KSchuilenburg HSmyth DSteck APhillips AMurphy RHatziagelaki ERisbeck HDonaghue KMaliszewska KDrury PHernandez MKurkhaus ACheung PTRubio-Cabezas OKosoy RBrowning BMarks JThompson SDGudgeon CLevin PPirags VBonnici FAnderson CPolychronakos CTeuschler HHansen JBarcellos LKretowski ANerup JYoukey JLathrop MHulbert EBrickman WCooper JDaly MLees CDuncanson AKaufman FDubois PCNorkus ADolan LMein CAGitelman SSchober EMcEvoy RAkolkar BGaudieri SShen SCherubini VTsalikian ERisch NGeraghty DCounts DSan Miguel FVBhaw-Rosun LWalter MErlich HFiallo-Scharer RHumphreys KMogollon FJHall ASLloyd MThomas AHan XChristensen RFranke AQu HCrock PThrailkill KBurren ODeloukas PLohman KMcKinnon EShe JXGorodezky CRosinger SBurton PRWahlen JHelmberg WField LGough SCOwerbach DIzquierdo RWeidinger SSkrha JField SMowat CDye SVertachnik KWellcome Trust Case Control ConsortiumGreer RDavison LEverett VSimmonds MJHilliker WFransen KMorahan GAly TWicker LSumnik ZClarke POnengut-Gumuscu SAlper CTrynka GGabriel SNicholson IGellert SBattelino TBarrett JCKnip MBronson PMin LBolidson JTodd JALoth ADevlin BRainbow KTuomilehto JSedimbi SKaiserman KRainbow DRamsay PAlemzadeh RHardy MHeap GABecker TJohannesen JHarrison DMiao DHarrison LMuller-Quernheim JBarrett JHarrison IRaj SNutland SBrorsson CValdes AMChaichanwatanakul KLawrence JStratton LKojo EJi LDoria ADownes KKanungo AMcIndoe RAdlem EHealy BCraddock NTaback SDrummond HEMarga MBecker DDonaldson DSale MGoodman NPierce JWilliams Dde Bakker PRacasan RWilliams ATaylor NJames INezhenstsev SSnively BSchreiber SSanjeevi CAmpudia-Blasco FGutierrez PSobngwi ESchatz DPosthumus MDVelickiene DHall MCrews AHe CBeilhack GSudman MMaisuria MBalschun TReboussin DHilner JMartinez MPvan Heel DASeufert JPost JAltshuler DNail JKek BTait BGravely JHunt KAZiegler AKuzmicki MParkes MDonnelly PCinek OPihoker CHarrington KWagenknecht LDixon PGuja CBrown MALouey ATrymbiski PTroyano MJMcKeon CGhosh SWijmenga CAldrich AKockum IDzivite IGodwin MHagopian WRich SSOlsson MCarlson JKinalska IHowell SRappaport MShtir CIonescu-Tirgoviste CHoffman RSur DBaskerville TAnastassiou DTheil GWilli SLi DMack SMeadows WEdkins SHunt SAbdul Ghani RLee YJFagulha AArora SLi XBalcells MFDuley SSamani NJHakonarson HBergholdt RTilmann VCrandall JHamon SJones TScott CSmyth DJAvbelj MLangford CRaskin PUrbanavicius VSomerville MMansfield JBerka NArgente JBain SMoran AMoore WPostellon DKamaruddin NAYing GSHarnish TMerkle LWeber SSmink LRosati GMoses RMerriman TSimpson ACooper JDBottini NType 1 Diabetes Genetics ConsortiumZhang HPatterson CAustin AWilson MZhang QVarney MSatsangi JAkwo EAJospe NKloos EChandler KToth ECucca FSpinas GMcCarthy MFolster-Holst RStender SJulier CConcannon PHosszufalusi NColeman GPerdue LWeersma RKVan der Auwera BMauricio DChen WMHurles MHattersley ATBriggs FPearce KBrodnicki TNewman WKrebs JRonningen SHood SCompston AOrban TLee JWhittaker PLevetan CThomson GHenderson PHofmann SRoep BOThomson ECuartero BGLie BAShao XEdwards CWherrett DTandon NAu KPrice GMadacsy LRaile KBrand OJCotterill AFerry RMickelson EGlass DNDias KRKanga UKim SWilson DAllen JHafler JUK Inflammatory Bowel Disease (IBD) Genetics ConsortiumGoland RCutfield RPanelo ABrady BEisenbarth GAhmad TCipponeri EAlbret LKumar NFain PRappner RColman PMoonsamy PBan MGarge NNolan DAnand VLavant EHuizinga TWDaniels MHepler JWang XPlagnol VElder JEl-Hajj RSatman IYang JWillis JKordonouri OHasan KBSawcer SRahman NMcGinnis RLu LLong AUndlien DRodriguez LWidmer BMehra NRodriguez HRich SHowson JMazurkievicz GRuckgaber CKnowles SBrouwer EPietropaolo MKing NRogers MEsposito LVandiedonck CMcLaren WPembrey MToes Rde Leiva AZhao LPLonsdale JBonella PClayton DZhernakova AWeerakulwattana PShulman DOvington NBrown MMagnuson VOtt JCameron FBrown JSteffes MHeilman KBoehm BCouper JfalseRare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry.2011-01-01T00:00:00Z2011 Dec2026-05-03T05:56:47.551Z2026-04-07T18:56:02.949ZS-EPMC32872922220076910.1038/ng.1037