biostudies-literatureTarini BANICHD NIH HHS446-61https://www.ebi.ac.uk/biostudies/studies/S-EPMC3288389biostudies-literatureUnknown47(1 Pt 2)<h4>Objective</h4>To estimate the impact of the mandatory National Collegiate Athletic Association (NCAA) sickle cell trait (SCT) screening policy on the identification of sickle cell carriers and prevention of sudden death.<h4>Data source</h4>We used NCAA reports, population-based SCT prevalence estimates, and published risks for exercise-related sudden death attributable to SCT.<h4>Study design</h4>We estimated the number of sickle cell carriers identified and the number of potentially preventable sudden deaths with mandatory SCT screening of NCAA Division I athletes. We calculated the number of student-athletes with SCT using a conditional probability based upon SCT prevalence data and self-identified race/ethnicity status. We estimated sudden deaths over 10 years based on published attributable risk of exercise-related sudden death due to SCT.<h4>Principal findings</h4>We estimate that over 2,000 NCAA Division I student-athletes with SCT will be identified under this screening policy and that, without intervention, about seven NCAA Division I student-athletes would die suddenly as a complication of SCT over a 10-year period.<h4>Conclusion</h4>Universal sickle cell screening of NCAA Division I student-athletes will identify a substantial number of sickle cell carriers. A successful intervention could prevent about seven deaths over a decade.Health services researchA policy impact analysis of the mandatory NCAA sickle cell trait screening program.PMC3288389K12 HD055894K23 HD057994-03K23 HD057994K23HD057994Tarini BABundy DGBrooks MAfalseA policy impact analysis of the mandatory NCAA sickle cell trait screening program.<h4>Objective</h4>To estimate the impact of the mandatory National Collegiate Athletic Association (NCAA) sickle cell trait (SCT) screening policy on the identification of sickle cell carriers and prevention of sudden death.<h4>Data source</h4>We used NCAA reports, population-based SCT prevalence estimates, and published risks for exercise-related sudden death attributable to SCT.<h4>Study design</h4>We estimated the number of sickle cell carriers identified and the number of potentially preventable sudden deaths with mandatory SCT screening of NCAA Division I athletes. We calculated the number of student-athletes with SCT using a conditional probability based upon SCT prevalence data and self-identified race/ethnicity status. We estimated sudden deaths over 10 years based on published attributable risk of exercise-related sudden death due to SCT.<h4>Principal findings</h4>We estimate that over 2,000 NCAA Division I student-athletes with SCT will be identified under this screening policy and that, without intervention, about seven NCAA Division I student-athletes would die suddenly as a complication of SCT over a 10-year period.<h4>Conclusion</h4>Universal sickle cell screening of NCAA Division I student-athletes will identify a substantial number of sickle cell carriers. A successful intervention could prevent about seven deaths over a decade.2012-01-01T00:00:00Z2012 Feb2024-11-08T17:21:00.449Z2019-03-27T00:49:31ZS-EPMC32883892215064710.1111/j.1475-6773.2011.01357.x