{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["El-Achkar TM"],"funding":["NIDDK NIH HHS"],"pagination":["452-61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3288726"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["59(3)"],"pubmed_abstract":["Uromodulin, also known as Tamm-Horsfall protein, is a glycoprotein expressed exclusively by renal tubular cells lining the thick ascending limb of the loop of Henle. Although the physiologic functions of this protein remain elusive, significant progress has been made during the last decade that highlights the importance of uromodulin in the pathophysiology of various diseases, such as medullary cystic kidney disease, urinary tract infections, and nephrolithiasis. Meanwhile, there is renewed interest in the role of uromodulin in kidney injury, both acute and chronic. In this article, we review the existing evidence that supports a role for uromodulin in acute kidney injury, chronic kidney disease, and renal inflammation. Contrary to the conventional view of uromodulin as an instigator in ki"],"journal":["American journal of kidney diseases : the official journal of the National Kidney Foundation"],"pubmed_title":["Uromodulin in kidney injury: an instigator, bystander, or protector?"],"pmcid":["PMC3288726"],"funding_grant_id":["R01 DK056903-01A1","R01 DK056903"],"pubmed_authors":["Wu XR","El-Achkar TM"],"additional_accession":[]},"is_claimable":false,"name":"Uromodulin in kidney injury: an instigator, bystander, or protector?","description":"Uromodulin, also known as Tamm-Horsfall protein, is a glycoprotein expressed exclusively by renal tubular cells lining the thick ascending limb of the loop of Henle. Although the physiologic functions of this protein remain elusive, significant progress has been made during the last decade that highlights the importance of uromodulin in the pathophysiology of various diseases, such as medullary cystic kidney disease, urinary tract infections, and nephrolithiasis. Meanwhile, there is renewed interest in the role of uromodulin in kidney injury, both acute and chronic. In this article, we review the existing evidence that supports a role for uromodulin in acute kidney injury, chronic kidney disease, and renal inflammation. Contrary to the conventional view of uromodulin as an instigator in ki","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2025-04-05T00:33:21.947Z","creation":"2019-03-27T00:49:33Z"},"accession":"S-EPMC3288726","cross_references":{"pubmed":["22277744"],"doi":["10.1053/j.ajkd.2011.10.054"]}}