{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Krehl S"],"funding":["NCI NIH HHS"],"pagination":["620-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3291858"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(3)"],"pubmed_abstract":["Chronic inflammation and selenium deficiency are considered as risk factors for colon cancer. The protective effect of selenium might be mediated by specific selenoproteins, such as glutathione peroxidases (GPx). GPx-1 and -2 double knockout, but not single knockout mice, spontaneously develop ileocolitis and intestinal cancer. Since GPx2 is induced by the chemopreventive sulforaphane (SFN) via the nuclear factor E2-related factor 2 (Nrf2)/Keap1 system, the susceptibility of GPx2-KO and wild-type (WT) mice to azoxymethane and dextran sulfate sodium (AOM/DSS)-induced colon carcinogenesis was tested under different selenium states and SFN applications. WT and GPx2-KO mice were grown on a selenium-poor, -adequate or -supranutritional diet. SFN application started either 1 week before (SFN4) o"],"journal":["Carcinogenesis"],"pubmed_title":["Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply."],"pmcid":["PMC3291858"],"funding_grant_id":["R01 CA114569"],"pubmed_authors":["Loewinger M","Banning A","Brauer MN","Chu FF","Esworthy RS","Florian S","Brigelius-Flohe R","Wessjohann LA","Kipp AP","Iori R","Krehl S"],"additional_accession":[]},"is_claimable":false,"name":"Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply.","description":"Chronic inflammation and selenium deficiency are considered as risk factors for colon cancer. The protective effect of selenium might be mediated by specific selenoproteins, such as glutathione peroxidases (GPx). GPx-1 and -2 double knockout, but not single knockout mice, spontaneously develop ileocolitis and intestinal cancer. Since GPx2 is induced by the chemopreventive sulforaphane (SFN) via the nuclear factor E2-related factor 2 (Nrf2)/Keap1 system, the susceptibility of GPx2-KO and wild-type (WT) mice to azoxymethane and dextran sulfate sodium (AOM/DSS)-induced colon carcinogenesis was tested under different selenium states and SFN applications. WT and GPx2-KO mice were grown on a selenium-poor, -adequate or -supranutritional diet. SFN application started either 1 week before (SFN4) o","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2025-04-04T14:12:38.025Z","creation":"2019-03-27T00:49:43Z"},"accession":"S-EPMC3291858","cross_references":{"pubmed":["22180572"],"doi":["10.1093/carcin/bgr288"]}}