{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["DuBose AJ"],"funding":["NICHD NIH HHS"],"pagination":["3446-50"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3295271"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["109(9)"],"pubmed_abstract":["Imprinted gene expression associated with Prader-Willi syndrome (PWS) and Angelman syndrome (AS) is controlled by two imprinting centers (ICs), the PWS-IC and the AS-IC. The PWS-IC operates in cis to activate transcription of genes that are expressed exclusively from the paternal allele. We have created a conditional allele of the PWS-IC to investigate its developmental activity. Deletion of the paternal PWS-IC in the embryo before implantation abolishes expression of the paternal-only genes in the neonatal brain. Surprisingly, deletion of the PWS-IC in early brain progenitors does not affect the subsequent imprinted status of PWS/AS genes in the newborn brain. These results indicate that the PWS-IC functions to protect the paternal epigenotype at the epiblast stage of development but is dispensable thereafter."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Temporal and developmental requirements for the Prader-Willi imprinting center."],"pmcid":["PMC3295271"],"funding_grant_id":["R01 HD 037872","R01 HD037872"],"pubmed_authors":["Resnick JL","DuBose AJ","Smith EY","Johnstone KA"],"additional_accession":[]},"is_claimable":false,"name":"Temporal and developmental requirements for the Prader-Willi imprinting center.","description":"Imprinted gene expression associated with Prader-Willi syndrome (PWS) and Angelman syndrome (AS) is controlled by two imprinting centers (ICs), the PWS-IC and the AS-IC. The PWS-IC operates in cis to activate transcription of genes that are expressed exclusively from the paternal allele. We have created a conditional allele of the PWS-IC to investigate its developmental activity. Deletion of the paternal PWS-IC in the embryo before implantation abolishes expression of the paternal-only genes in the neonatal brain. Surprisingly, deletion of the PWS-IC in early brain progenitors does not affect the subsequent imprinted status of PWS/AS genes in the newborn brain. These results indicate that the PWS-IC functions to protect the paternal epigenotype at the epiblast stage of development but is dispensable thereafter.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Feb","modification":"2025-04-29T09:57:28.698Z","creation":"2019-03-27T00:50:54Z"},"accession":"S-EPMC3295271","cross_references":{"pubmed":["22331910"],"doi":["10.1073/pnas.1115057109"]}}