{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(3)"],"submitter":["Shufelt C"],"pubmed_abstract":["Background
An increased risk of breast cancer is associated with alcohol consumption; however, it is controversial whether red wine increases this risk. Aromatase inhibitors (AIs) prevent the conversion of androgens to estrogen and occur naturally in grapes, grape juice, and red, but not white wine. We tested whether red wine is a nutritional AI in premenopausal women.Methods
In a cross-over design, 36 women (mean age [SD], 36 [8] years) were assigned to 8 ounces (237 mL) of red wine daily then white wine for 1 month each, or the reverse. Blood was collected twice during the menstrual cycle for measurement of estradiol (E2), estrone (E1), androstenedione (A), total and free testosterone (T), sex hormone binding globulin (SHBG), luteinizing hormone (LH), and follicle stimula"],"journal":["Journal of women's health (2002)"],"pagination":["281-4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3298670"],"repository":["biostudies-literature"],"pubmed_title":["Red versus white wine as a nutritional aromatase inhibitor in premenopausal women: a pilot study."],"pmcid":["PMC3298670"],"pubmed_authors":["Polk D","Yang Y","Shufelt C","Merz CN","Stanczyk F","Kirschner J","Paul-Labrador M","Braunstein GD"],"additional_accession":[]},"is_claimable":false,"name":"Red versus white wine as a nutritional aromatase inhibitor in premenopausal women: a pilot study.","description":"Background
An increased risk of breast cancer is associated with alcohol consumption; however, it is controversial whether red wine increases this risk. Aromatase inhibitors (AIs) prevent the conversion of androgens to estrogen and occur naturally in grapes, grape juice, and red, but not white wine. We tested whether red wine is a nutritional AI in premenopausal women.Methods
In a cross-over design, 36 women (mean age [SD], 36 [8] years) were assigned to 8 ounces (237 mL) of red wine daily then white wine for 1 month each, or the reverse. Blood was collected twice during the menstrual cycle for measurement of estradiol (E2), estrone (E1), androstenedione (A), total and free testosterone (T), sex hormone binding globulin (SHBG), luteinizing hormone (LH), and follicle stimula","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2025-04-20T03:33:40.26Z","creation":"2019-06-05T17:08:22Z"},"accession":"S-EPMC3298670","cross_references":{"pubmed":["22150098"],"doi":["10.1089/jwh.2011.3001"]}}