{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tso FY"],"funding":["NCRR NIH HHS","FIC NIH HHS","NIAID NIH HHS","NCI NIH HHS","Engineering and Physical Sciences Research Council"],"pagination":["e32827"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3299704"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(3)"],"pubmed_abstract":["Understanding the evolution of the human immunodeficiency virus type 1 (HIV-1) envelope during disease progression can provide tremendous insights for vaccine development, and simian-human immunodeficiency virus (SHIV) infection of non-human primate provides an ideal platform for such studies. A newly developed clade C SHIV, SHIV-1157ipd3N4, which was able to infect rhesus macaques, closely resembled primary HIV-1 in transmission and pathogenesis, was used to infect several pig-tailed macaques. One of the infected animals subsequently progressed to AIDS, whereas one remained a non-progressor. The viral envelope evolution in the infected animals during disease progression was analyzed by a bioinformatics approach using ultra-deep pyrosequencing. Our results showed substantial envelope varia"],"journal":["PloS one"],"pubmed_title":["Dynamics of envelope evolution in clade C SHIV-infected pig-tailed macaques during disease progression analyzed by ultra-deep pyrosequencing."],"pmcid":["PMC3299704"],"funding_grant_id":["RR000166","P01 AI048240","P30 RR031151","R01 CA075903","T32 AI060547","TW001429","P51 RR000166","EP/H003851/1","P01 AI48240","CA75903","N01 AI060006","D43 TW001429","3P01AI048240-08S1"],"pubmed_authors":["Ruprecht RM","Hu SL","Ho O","Wood C","Tully DC","Gonzalez S","Tso FY","Polacino P","Quince C"],"additional_accession":[]},"is_claimable":false,"name":"Dynamics of envelope evolution in clade C SHIV-infected pig-tailed macaques during disease progression analyzed by ultra-deep pyrosequencing.","description":"Understanding the evolution of the human immunodeficiency virus type 1 (HIV-1) envelope during disease progression can provide tremendous insights for vaccine development, and simian-human immunodeficiency virus (SHIV) infection of non-human primate provides an ideal platform for such studies. A newly developed clade C SHIV, SHIV-1157ipd3N4, which was able to infect rhesus macaques, closely resembled primary HIV-1 in transmission and pathogenesis, was used to infect several pig-tailed macaques. One of the infected animals subsequently progressed to AIDS, whereas one remained a non-progressor. The viral envelope evolution in the infected animals during disease progression was analyzed by a bioinformatics approach using ultra-deep pyrosequencing. Our results showed substantial envelope varia","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2026-04-07T20:46:31.542Z","creation":"2026-04-07T17:47:06.231Z"},"accession":"S-EPMC3299704","cross_references":{"pubmed":["22427893"],"doi":["10.1371/journal.pone.0032827"]}}