biostudies-literatureLiu EBNEI NIH HHSe33212https://www.ebi.ac.uk/biostudies/studies/S-EPMC3302849biostudies-literatureUnknown7(3)In November of 2007 a human adenovirus (HAdV) was isolated from a bronchoalveolar lavage (BAL) sample recovered from a biopsy of an AIDS patient who presented with fever, cough, tachycardia, and expiratory wheezes. To better understand the isolated virus, the genome was sequenced and analyzed using bioinformatic and phylogenomic analysis. The results suggest that this novel virus, which is provisionally named HAdV-D59, may have been created from multiple recombination events. Specifically, the penton, hexon, and fiber genes have high nucleotide identity to HAdV-D19C, HAdV-D25, and HAdV-D56, respectively. Serological results demonstrated that HAdV-D59 has a neutralization profile that is similar yet not identical to that of HAdV-D25. Furthermore, we observed a two-fold difference between thPloS oneComputational and serologic analysis of novel and known viruses in species human adenovirus D in which serology and genomics do not correlate.PMC3302849R01 EY013124R01EY013124P30 EY014104P30EY014104Seto JVu MDyer DWSeto DLiu EBTorres SChodosh JWadford DAHudson NRJones MSThrasher LfalseComputational and serologic analysis of novel and known viruses in species human adenovirus D in which serology and genomics do not correlate.In November of 2007 a human adenovirus (HAdV) was isolated from a bronchoalveolar lavage (BAL) sample recovered from a biopsy of an AIDS patient who presented with fever, cough, tachycardia, and expiratory wheezes. To better understand the isolated virus, the genome was sequenced and analyzed using bioinformatic and phylogenomic analysis. The results suggest that this novel virus, which is provisionally named HAdV-D59, may have been created from multiple recombination events. Specifically, the penton, hexon, and fiber genes have high nucleotide identity to HAdV-D19C, HAdV-D25, and HAdV-D56, respectively. Serological results demonstrated that HAdV-D59 has a neutralization profile that is similar yet not identical to that of HAdV-D25. Furthermore, we observed a two-fold difference between th2012-01-01T00:00:00Z20122025-04-19T14:02:38.903Z2019-03-26T23:18:29ZS-EPMC33028492242799210.1371/journal.pone.0033212