{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Toda K"],"pubmed_abstract":["<h4>Background</h4>The spindle assembly checkpoint (SAC) inhibits anaphase progression in the presence of insufficient kinetochore-microtubule attachments, but cells can eventually override mitotic arrest by a process known as mitotic slippage or adaptation. This is a problem for cancer chemotherapy using microtubule poisons.<h4>Results</h4>Here we describe mitotic slippage in yeast bub2Δ mutant cells that are defective in the repression of precocious telophase onset (mitotic exit). Precocious activation of anaphase promoting complex/cyclosome (APC/C)-Cdh1 caused mitotic slippage in the presence of nocodazole, while the SAC was still active. APC/C-Cdh1, but not APC/C-Cdc20, triggered anaphase progression (securin degradation, separase-mediated cohesin cleavage, sister-chromatid separation "],"journal":["Cell division"],"pagination":["4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3305350"],"repository":["biostudies-literature"],"pubmed_title":["APC/C-Cdh1-dependent anaphase and telophase progression during mitotic slippage."],"pmcid":["PMC3305350"],"pubmed_authors":["Ueno M","Toda K","Naito K","Mase S","Uritani M","Yamamoto A","Ushimaru T"],"additional_accession":[]},"is_claimable":false,"name":"APC/C-Cdh1-dependent anaphase and telophase progression during mitotic slippage.","description":"<h4>Background</h4>The spindle assembly checkpoint (SAC) inhibits anaphase progression in the presence of insufficient kinetochore-microtubule attachments, but cells can eventually override mitotic arrest by a process known as mitotic slippage or adaptation. This is a problem for cancer chemotherapy using microtubule poisons.<h4>Results</h4>Here we describe mitotic slippage in yeast bub2Δ mutant cells that are defective in the repression of precocious telophase onset (mitotic exit). Precocious activation of anaphase promoting complex/cyclosome (APC/C)-Cdh1 caused mitotic slippage in the presence of nocodazole, while the SAC was still active. APC/C-Cdh1, but not APC/C-Cdc20, triggered anaphase progression (securin degradation, separase-mediated cohesin cleavage, sister-chromatid separation ","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Feb","modification":"2026-04-07T23:06:55.897Z","creation":"2026-04-07T18:54:35.839Z"},"accession":"S-EPMC3305350","cross_references":{"pubmed":["22321970"],"doi":["10.1186/1747-1028-7-4"]}}