biostudies-literatureUnknown7Toda K<h4>Background</h4>The spindle assembly checkpoint (SAC) inhibits anaphase progression in the presence of insufficient kinetochore-microtubule attachments, but cells can eventually override mitotic arrest by a process known as mitotic slippage or adaptation. This is a problem for cancer chemotherapy using microtubule poisons.<h4>Results</h4>Here we describe mitotic slippage in yeast bub2Δ mutant cells that are defective in the repression of precocious telophase onset (mitotic exit). Precocious activation of anaphase promoting complex/cyclosome (APC/C)-Cdh1 caused mitotic slippage in the presence of nocodazole, while the SAC was still active. APC/C-Cdh1, but not APC/C-Cdc20, triggered anaphase progression (securin degradation, separase-mediated cohesin cleavage, sister-chromatid separation Cell division4https://www.ebi.ac.uk/biostudies/studies/S-EPMC3305350biostudies-literatureAPC/C-Cdh1-dependent anaphase and telophase progression during mitotic slippage.PMC3305350Ueno MToda KNaito KMase SUritani MYamamoto AUshimaru TfalseAPC/C-Cdh1-dependent anaphase and telophase progression during mitotic slippage.<h4>Background</h4>The spindle assembly checkpoint (SAC) inhibits anaphase progression in the presence of insufficient kinetochore-microtubule attachments, but cells can eventually override mitotic arrest by a process known as mitotic slippage or adaptation. This is a problem for cancer chemotherapy using microtubule poisons.<h4>Results</h4>Here we describe mitotic slippage in yeast bub2Δ mutant cells that are defective in the repression of precocious telophase onset (mitotic exit). Precocious activation of anaphase promoting complex/cyclosome (APC/C)-Cdh1 caused mitotic slippage in the presence of nocodazole, while the SAC was still active. APC/C-Cdh1, but not APC/C-Cdc20, triggered anaphase progression (securin degradation, separase-mediated cohesin cleavage, sister-chromatid separation 2012-01-01T00:00:00Z2012 Feb2026-04-07T23:06:55.897Z2026-04-07T18:54:35.839ZS-EPMC33053502232197010.1186/1747-1028-7-4