biostudies-literatureUnknown106(5)Liu WM<h4>Background</h4>There is evidence that tumours produce substances such as cytokines and microvesicular bodies bearing bioactive molecules, which support the carcinogenic process. Furthermore, chemotherapy has also been shown to modify these exudates and in doing so, neutralise their tumourigenic influence.<h4>Methods</h4>In the current study, we have investigated the effect of chemotherapy agents on modifying the cytokine profile and microvesicular cargo of supernatants derived from cancer cell lines. In addition, we have explored the effect of these tumour-derived supernatants on angiogenesis, and how chemotherapy can alter the supernatants rendering them less pro-angiogenic.<h4>Results</h4>Herein, we show that supernatants contain a rich cocktail of cytokines, a number of which are poBritish journal of cancer896-903https://www.ebi.ac.uk/biostudies/studies/S-EPMC3305950biostudies-literatureSupernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis.PMC3305950Bodman-Smith MCoulton GLiu WMDennis JLFowler DWDalgleish AGGravett AMChanthirakumar CKaminska EfalseSupernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis.<h4>Background</h4>There is evidence that tumours produce substances such as cytokines and microvesicular bodies bearing bioactive molecules, which support the carcinogenic process. Furthermore, chemotherapy has also been shown to modify these exudates and in doing so, neutralise their tumourigenic influence.<h4>Methods</h4>In the current study, we have investigated the effect of chemotherapy agents on modifying the cytokine profile and microvesicular cargo of supernatants derived from cancer cell lines. In addition, we have explored the effect of these tumour-derived supernatants on angiogenesis, and how chemotherapy can alter the supernatants rendering them less pro-angiogenic.<h4>Results</h4>Herein, we show that supernatants contain a rich cocktail of cytokines, a number of which are po2012-01-01T00:00:00Z2012 Feb2025-04-04T11:51:58.124Z2019-03-27T00:51:14ZS-EPMC33059502229418610.1038/bjc.2012.13