biostudies-literaturePirooznia MNIMH NIH HHS897-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC3307115biostudies-literatureUnknown28(6)<h4>Motivation</h4>The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking.<h4>Results</h4>We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.Bioinformatics (Oxford, England)SynaptomeDB: an ontology-based knowledgebase for synaptic genes.PMC3307115R01-MH087979K01-MH093809R01 MH087979R01-MH083738K01 MH093809Potash JBPirooznia MWang TZandi PPThomas GAvramopoulos DValle DHuganir RLGoes FSfalseSynaptomeDB: an ontology-based knowledgebase for synaptic genes.<h4>Motivation</h4>The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking.<h4>Results</h4>We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.2012-01-01T00:00:00Z2012 Mar2026-04-30T20:37:13.98Z2019-03-27T00:51:20ZS-EPMC33071152228556410.1093/bioinformatics/bts040