{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["287(12)"],"submitter":["Lee S"],"pubmed_abstract":["Prostaglandin D synthase (PGDS) is responsible for the conversion of PGH(2) to PGD(2). Two distinct types of PGDS have been identified: hematopoietic-type PGDS (H-PGDS) and lipocalin-type PGDS (L-PGDS). L-PGDS acts as both a PGD(2)-synthesizing enzyme and as an extracellular transporter of various lipophilic small molecules. Although L-PGDS is one of the most abundant proteins in the cerebrospinal fluid, little is known about the function of L-PGDS in the central nervous system (CNS). To better understand the role of L-PGDS in the CNS, effects of L-PGDS on the migration and morphology of glial cells were investigated. The L-PGDS protein accelerated the migration of cultured glial cells. Expression of the L-pgds gene was detected in glial cells and neurons. L-PGDS protein also induced morph"],"journal":["The Journal of biological chemistry"],"pagination":["9414-28"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3308805"],"repository":["biostudies-literature"],"pubmed_title":["Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-kinase substrate: prostaglandin D2-independent effects."],"pmcid":["PMC3308805"],"pubmed_authors":["Lee S","Jang E","Kim JH","Lee WH","Suk K"],"additional_accession":[]},"is_claimable":false,"name":"Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-kinase substrate: prostaglandin D2-independent effects.","description":"Prostaglandin D synthase (PGDS) is responsible for the conversion of PGH(2) to PGD(2). Two distinct types of PGDS have been identified: hematopoietic-type PGDS (H-PGDS) and lipocalin-type PGDS (L-PGDS). L-PGDS acts as both a PGD(2)-synthesizing enzyme and as an extracellular transporter of various lipophilic small molecules. Although L-PGDS is one of the most abundant proteins in the cerebrospinal fluid, little is known about the function of L-PGDS in the central nervous system (CNS). To better understand the role of L-PGDS in the CNS, effects of L-PGDS on the migration and morphology of glial cells were investigated. The L-PGDS protein accelerated the migration of cultured glial cells. Expression of the L-pgds gene was detected in glial cells and neurons. L-PGDS protein also induced morph","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2025-04-05T12:06:53.758Z","creation":"2019-03-27T00:51:25Z"},"accession":"S-EPMC3308805","cross_references":{"pubmed":["22275363"],"doi":["10.1074/jbc.m111.330662","10.1074/jbc.M111.330662"]}}