{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(3)"],"submitter":["An S"],"pubmed_abstract":["<h4>Background</h4>Bursicon is a heterodimer neuropeptide composed of two cystine knot proteins, bursicon α (burs α) and bursicon β (burs β), that elicits cuticle tanning (melanization and sclerotization) through the Drosophila leucine-rich repeats-containing G protein-coupled receptor 2 (DLGR2). Recent studies show that both bursicon subunits also form homodimers. However, biological functions of the homodimers have remained unknown until now.<h4>Methodology/principal findings</h4>In this report, we show in Drosophila melanogaster that both bursicon homodimers induced expression of genes encoding antimicrobial peptides (AMPs) in neck-ligated adults following recombinant homodimer injection and in larvae fat body after incubation with recombinant homodimers. These AMP genes were also up-re"],"journal":["PloS one"],"pagination":["e34510"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3314635"],"repository":["biostudies-literature"],"pubmed_title":["Insect neuropeptide bursicon homodimers induce innate immune and stress genes during molting by activating the NF-κB transcription factor Relish."],"pmcid":["PMC3314635"],"pubmed_authors":["Wang Q","Li S","Song Q","Gilbert LI","Stanley D","Dong S","An S"],"additional_accession":[]},"is_claimable":false,"name":"Insect neuropeptide bursicon homodimers induce innate immune and stress genes during molting by activating the NF-κB transcription factor Relish.","description":"<h4>Background</h4>Bursicon is a heterodimer neuropeptide composed of two cystine knot proteins, bursicon α (burs α) and bursicon β (burs β), that elicits cuticle tanning (melanization and sclerotization) through the Drosophila leucine-rich repeats-containing G protein-coupled receptor 2 (DLGR2). Recent studies show that both bursicon subunits also form homodimers. However, biological functions of the homodimers have remained unknown until now.<h4>Methodology/principal findings</h4>In this report, we show in Drosophila melanogaster that both bursicon homodimers induced expression of genes encoding antimicrobial peptides (AMPs) in neck-ligated adults following recombinant homodimer injection and in larvae fat body after incubation with recombinant homodimers. These AMP genes were also up-re","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2025-04-21T22:48:23.024Z","creation":"2019-03-26T23:12:54Z"},"accession":"S-EPMC3314635","cross_references":{"pubmed":["22470576"],"doi":["10.1371/journal.pone.0034510"]}}