{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lambert C"],"funding":["National Institute for Health Research (NIHR)","Department of Health NIHR Biomedical Research Centres","Wellcome Trust"],"pagination":["83-94"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3315017"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["60(1)"],"pubmed_abstract":["The subthalamic nucleus (STN) is a small, glutamatergic nucleus situated in the diencephalon. A critical component of normal motor function, it has become a key target for deep brain stimulation in the treatment of Parkinson's disease. Animal studies have demonstrated the existence of three functional sub-zones but these have never been shown conclusively in humans. In this work, a data driven method with diffusion weighted imaging demonstrated that three distinct clusters exist within the human STN based on brain connectivity profiles. The STN was successfully sub-parcellated into these regions, demonstrating good correspondence with that described in the animal literature. The local connectivity of each sub-region supported the hypothesis of bilateral limbic, associative and motor region"],"journal":["NeuroImage"],"pubmed_title":["Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging."],"pmcid":["PMC3315017"],"funding_grant_id":["091593","075696/Z/04/Z","CL-2012-16-501","091593/Z/10/Z"],"pubmed_authors":["Draganski B","Ashburner J","Lutti A","Lambert C","Hariz M","Zrinzo L","Foltynie T","Frackowiak R","Nagy Z"],"additional_accession":[]},"is_claimable":false,"name":"Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging.","description":"The subthalamic nucleus (STN) is a small, glutamatergic nucleus situated in the diencephalon. A critical component of normal motor function, it has become a key target for deep brain stimulation in the treatment of Parkinson's disease. Animal studies have demonstrated the existence of three functional sub-zones but these have never been shown conclusively in humans. In this work, a data driven method with diffusion weighted imaging demonstrated that three distinct clusters exist within the human STN based on brain connectivity profiles. The STN was successfully sub-parcellated into these regions, demonstrating good correspondence with that described in the animal literature. The local connectivity of each sub-region supported the hypothesis of bilateral limbic, associative and motor region","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2026-05-29T17:15:33.909Z","creation":"2019-03-27T00:51:42Z"},"accession":"S-EPMC3315017","cross_references":{"pubmed":["22173294"],"doi":["10.1016/j.neuroimage.2011.11.082"]}}