{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dastani Z"],"funding":["Intramural NIH HHS","British Heart Foundation","NCATS NIH HHS","NICHD NIH HHS","NCRR NIH HHS","NIA NIH HHS","NIEHS NIH HHS","FIC NIH HHS","NHLBI NIH HHS","NNF Center for Basic Metabolic Research","Vivensa Foundation","CIHR","NIDDK NIH HHS","Medical Research Council","NIMHD NIH HHS","National Institute for Health Research (NIHR)","NHGRI NIH HHS","European Commission FP7","Chief Scientist Office","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["e1002607"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3315470"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(3)"],"pubmed_abstract":["Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adipone"],"journal":["PLoS genetics"],"pubmed_title":["Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals."],"pmcid":["PMC3315470"],"funding_grant_id":["P20 MD006899","RC2 HL102419","U1475000001","K08 DK002600","U1475000002","MC_U127592696","UL1 RR025008","UL1 RR025005","UL1 RR024156","1 R01 DK075787-01A1","PG/08/094/26019","R01-HL085251","G0801056B","UL1 TR000124","MC_U137686857","G0800582","R01 DK075787","R01 HL094555","N01 HC055222","N01 HC-55222","M01 RR000425","R01 DK056918","G19/35","P30 DK063491","MC_PC_U127561128","G0901213","N01-HC-75150","CZB/4/710","MC_U147585824","U01 HG004402","UL1 TR000454","N01-HC-85079","RR-024156","N01-HC-95161","U01 HL080295","N01-HC-65226","N01-HC-95162","N01-HC-95163","N01-HC-95164","G0600717","N01-HC-95160","N01 HC025195","N01 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for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.","description":"Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adipone","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2026-05-01T08:25:11.399Z","creation":"2026-04-07T16:47:19.194Z"},"accession":"S-EPMC3315470","cross_references":{"pubmed":["22479202"],"doi":["10.1371/journal.pgen.1002607"]}}