biostudies-literatureDastani ZIntramural NIH HHSBritish Heart FoundationNCATS NIH HHSNICHD NIH HHSNCRR NIH HHSNIA NIH HHSNIEHS NIH HHSFIC NIH HHSNHLBI NIH HHSNNF Center for Basic Metabolic ResearchVivensa FoundationCIHRNIDDK NIH HHSMedical Research CouncilNIMHD NIH HHSNational Institute for Health Research (NIHR)NHGRI NIH HHSEuropean Commission FP7Chief Scientist OfficeWellcome TrustBiotechnology and Biological Sciences Research Councile1002607https://www.ebi.ac.uk/biostudies/studies/S-EPMC3315470biostudies-literatureUnknown8(3)Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponePLoS geneticsNovel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.PMC3315470P20 MD006899RC2 HL102419U1475000001K08 DK002600U1475000002MC_U127592696UL1 RR025008UL1 RR025005UL1 RR0241561 R01 DK075787-01A1PG/08/094/26019R01-HL085251G0801056BUL1 TR000124MC_U137686857G0800582R01 DK075787R01 HL094555N01 HC055222N01 HC-55222M01 RR000425R01 DK056918G19/35P30 DK063491MC_PC_U127561128G0901213N01-HC-75150CZB/4/710MC_U147585824U01 HG004402UL1 TR000454N01-HC-85079RR-024156N01-HC-95161U01 HL080295N01-HC-65226N01-HC-95162N01-HC-95163N01-HC-95164G0600717N01-HC-95160N01 HC025195N01 HC055015N01 HC055016N01-HC-85080HHSN268200782096CN01 HC055018N01 HC055019N02-HL-6-4278N01-HC-85085N01-HC-85086064890N01-HC-85083G0902037N01-HC-85084N01-HC-85081R01HL086694N01-HC-85082R01 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JHallmans GPeloso GMBarter POostra BAPfeiffer AFWu YWright AFGo MJPark TMuTHER ConsortiumWong TYCouper DJSeedorf UMooser VMAGIC ConsortiumLajunen TDoney AO'Connell JHamsten AKraft PAdair LSRader DJTaylor HAPlatou CLadouceur MPolasek OMorken MAKapur KASteinthorsdottir VDuncan BBvan Herpt Tvan Duijn CSong KHung JBalkau BBandinelli SIsaacs AHide WASchlessinger DDominiczak AFKim YJBenediktsson RSoranzo NLehtimaki TJohnson PRKarpe FUda MPichler IProenca CCooper MNGraessler JThompson JRJanssens ACStrachan DPGreenwood CMMasson DLangenberg CSladek RSim XMagnusson PKSpranger JBarbalic MCampbell HSmith GDWillems SMJorgensen TGlazer NLMusani SPaulweber BZethelius BfalseNovel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adipone2012-01-01T00:00:00Z20122026-05-01T08:25:11.399Z2026-04-07T16:47:19.194ZS-EPMC33154702247920210.1371/journal.pgen.1002607