{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["Howard Hughes Medical Institute","NHGRI NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["908-21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3320767"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["148(5)"],"pubmed_abstract":["The extent to which the three-dimensional organization of the genome contributes to chromosomal translocations is an important question in cancer genomics. We generated a high-resolution Hi-C spatial organization map of the G1-arrested mouse pro-B cell genome and used high-throughput genome-wide translocation sequencing to map translocations from target DNA double-strand breaks (DSBs) within it. RAG endonuclease-cleaved antigen-receptor loci are dominant translocation partners for target DSBs regardless of genomic position, reflecting high-frequency DSBs at these loci and their colocalization in a fraction of cells. To directly assess spatial proximity contributions, we normalized genomic DSBs via ionizing radiation. Under these conditions, translocations were highly enriched in cis along "],"journal":["Cell"],"pubmed_title":["Spatial organization of the mouse genome and its role in recurrent chromosomal translocations."],"pmcid":["PMC3320767"],"funding_grant_id":["R01 HG003143","3P01CA092625-09S1","P01 CA092625","P01 CA092625-09","F32 GM100617","R01 HG003143-07"],"pubmed_authors":["Becker MS","Simon AC","McCord RP","Ho YJ","Hildebrand DG","Zhang Y","Dekker J","Alt FW","Lajoie BR"],"additional_accession":[]},"is_claimable":false,"name":"Spatial organization of the mouse genome and its role in recurrent chromosomal translocations.","description":"The extent to which the three-dimensional organization of the genome contributes to chromosomal translocations is an important question in cancer genomics. We generated a high-resolution Hi-C spatial organization map of the G1-arrested mouse pro-B cell genome and used high-throughput genome-wide translocation sequencing to map translocations from target DNA double-strand breaks (DSBs) within it. RAG endonuclease-cleaved antigen-receptor loci are dominant translocation partners for target DSBs regardless of genomic position, reflecting high-frequency DSBs at these loci and their colocalization in a fraction of cells. To directly assess spatial proximity contributions, we normalized genomic DSBs via ionizing radiation. Under these conditions, translocations were highly enriched in cis along ","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2025-04-04T21:05:48.984Z","creation":"2019-03-27T00:52:00Z"},"accession":"S-EPMC3320767","cross_references":{"pubmed":["22341456"],"doi":["10.1016/j.cell.2012.02.002"]}}