{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Johnson HM"],"funding":["NIDA NIH HHS","NCRR NIH HHS","NHLBI NIH HHS","NCI NIH HHS","Wellcome Trust"],"pagination":["e35332"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3322167"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(4)"],"pubmed_abstract":["<h4>Background</h4>The mechanisms by which smoking cessation reduces cardiovascular disease risk are unclear. We evaluated longitudinal changes in carotid intima-media thickness among current smokers enrolled in a prospective, randomized smoking cessation clinical trial.<h4>Methodology/principal findings</h4>Subjects were enrolled in a randomized, double-blind, placebo-controlled trial of 5 smoking cessation pharmacotherapies and underwent carotid ultrasonography with carotid intima-media thickness measurement. Subjects were classified as continuously abstinent (biochemically confirmed abstinence at 6 months, 1 year, and 3 years post-quit attempt), intermittently abstinent (reported smoking at one of the three time points), or smoked continuously (reported smoking at all three time points)"],"journal":["PloS one"],"pubmed_title":["Effects of smoking and cessation on subclinical arterial disease: a substudy of a randomized controlled trial."],"pmcid":["PMC3322167"],"funding_grant_id":["K05 CA139871","T32 HL007936","T32 HL07936","R01 HL109031","P50 DA019706","UL1 RR025011"],"pubmed_authors":["Baker TB","Johnson HM","Fiore MC","Piper ME","Stein JH"],"additional_accession":[]},"is_claimable":false,"name":"Effects of smoking and cessation on subclinical arterial disease: a substudy of a randomized controlled trial.","description":"<h4>Background</h4>The mechanisms by which smoking cessation reduces cardiovascular disease risk are unclear. We evaluated longitudinal changes in carotid intima-media thickness among current smokers enrolled in a prospective, randomized smoking cessation clinical trial.<h4>Methodology/principal findings</h4>Subjects were enrolled in a randomized, double-blind, placebo-controlled trial of 5 smoking cessation pharmacotherapies and underwent carotid ultrasonography with carotid intima-media thickness measurement. Subjects were classified as continuously abstinent (biochemically confirmed abstinence at 6 months, 1 year, and 3 years post-quit attempt), intermittently abstinent (reported smoking at one of the three time points), or smoked continuously (reported smoking at all three time points)","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2026-05-04T17:50:52.123Z","creation":"2019-03-26T23:18:33Z"},"accession":"S-EPMC3322167","cross_references":{"pubmed":["22496918"],"doi":["10.1371/journal.pone.0035332"]}}