biostudies-literatureJohnson HMNIDA NIH HHSNCRR NIH HHSNHLBI NIH HHSNCI NIH HHSWellcome Truste35332https://www.ebi.ac.uk/biostudies/studies/S-EPMC3322167biostudies-literatureUnknown7(4)<h4>Background</h4>The mechanisms by which smoking cessation reduces cardiovascular disease risk are unclear. We evaluated longitudinal changes in carotid intima-media thickness among current smokers enrolled in a prospective, randomized smoking cessation clinical trial.<h4>Methodology/principal findings</h4>Subjects were enrolled in a randomized, double-blind, placebo-controlled trial of 5 smoking cessation pharmacotherapies and underwent carotid ultrasonography with carotid intima-media thickness measurement. Subjects were classified as continuously abstinent (biochemically confirmed abstinence at 6 months, 1 year, and 3 years post-quit attempt), intermittently abstinent (reported smoking at one of the three time points), or smoked continuously (reported smoking at all three time points)PloS oneEffects of smoking and cessation on subclinical arterial disease: a substudy of a randomized controlled trial.PMC3322167K05 CA139871T32 HL007936T32 HL07936R01 HL109031P50 DA019706UL1 RR025011Baker TBJohnson HMFiore MCPiper MEStein JHfalseEffects of smoking and cessation on subclinical arterial disease: a substudy of a randomized controlled trial.<h4>Background</h4>The mechanisms by which smoking cessation reduces cardiovascular disease risk are unclear. We evaluated longitudinal changes in carotid intima-media thickness among current smokers enrolled in a prospective, randomized smoking cessation clinical trial.<h4>Methodology/principal findings</h4>Subjects were enrolled in a randomized, double-blind, placebo-controlled trial of 5 smoking cessation pharmacotherapies and underwent carotid ultrasonography with carotid intima-media thickness measurement. Subjects were classified as continuously abstinent (biochemically confirmed abstinence at 6 months, 1 year, and 3 years post-quit attempt), intermittently abstinent (reported smoking at one of the three time points), or smoked continuously (reported smoking at all three time points)2012-01-01T00:00:00Z20122026-05-04T17:50:52.123Z2019-03-26T23:18:33ZS-EPMC33221672249691810.1371/journal.pone.0035332