{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["287(13)"],"submitter":["Okuda-Ashitaka E"],"pubmed_abstract":["4-Nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) is a molecule of physiologically unknown function, although it is predominantly expressed in the brain, spinal cord, liver, and kidney. We identified NIPSNAP1 as a protein that interacts with the neuropeptide nocistatin (NST) from synaptosomal membranes of mouse spinal cord using high-performance affinity latex beads. NST, which is produced from the same precursor protein as an opioid-like neuropeptide nociceptin/orphanin FQ (N/OFQ), has opposite effects on pain transmission evoked by N/OFQ. The calculated full-length pre-protein of NIPSNAP1 was 33 kDa, whereas the N-terminal truncated form of NIPSNAP1 (29 kDa) was ubiquitously expressed in the neuronal tissues, especially in synaptic membrane and mit"],"journal":["The Journal of biological chemistry"],"pagination":["10403-10413"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3322983"],"repository":["biostudies-literature"],"pubmed_title":["Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission."],"pmcid":["PMC3322983"],"pubmed_authors":["Tsubouchi S","Noda T","Minami T","Iwamatsu A","Handa H","Okuda-Ashitaka E","Ito S","Kiyonari H"],"additional_accession":[]},"is_claimable":false,"name":"Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission.","description":"4-Nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) is a molecule of physiologically unknown function, although it is predominantly expressed in the brain, spinal cord, liver, and kidney. We identified NIPSNAP1 as a protein that interacts with the neuropeptide nocistatin (NST) from synaptosomal membranes of mouse spinal cord using high-performance affinity latex beads. NST, which is produced from the same precursor protein as an opioid-like neuropeptide nociceptin/orphanin FQ (N/OFQ), has opposite effects on pain transmission evoked by N/OFQ. The calculated full-length pre-protein of NIPSNAP1 was 33 kDa, whereas the N-terminal truncated form of NIPSNAP1 (29 kDa) was ubiquitously expressed in the neuronal tissues, especially in synaptic membrane and mit","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2025-04-22T19:17:11.16Z","creation":"2019-06-05T17:13:08Z"},"accession":"S-EPMC3322983","cross_references":{"pubmed":["22311985"],"doi":["10.1074/jbc.M111.271866","10.1074/jbc.m111.271866"]}}