{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kroenke MA"],"funding":["NCRR NIH HHS","NIAID NIH HHS"],"pagination":["3734-44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3324673"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["188(8)"],"pubmed_abstract":["Follicular helper CD4 T (Tfh) cells provide B cells with signals that are important for the generation of high-affinity Abs and immunological memory and, therefore, are critical for the protective immunity elicited by most human vaccines. Transcriptional regulators of human Tfh cell differentiation are poorly understood. In this article, we demonstrate that Bcl6 controls specific gene modules for human Tfh cell differentiation. The introduction of Bcl6 expression in primary human CD4 T cells resulted in the regulation of a core set of migration genes that enable trafficking to germinal centers: CXCR4, CXCR5, CCR7, and EBI2. Bcl6 expression also induced a module of protein expression critical for T-B interactions, including SAP, CD40L, PD-1, ICOS, and CXCL13. This constitutes direct evidenc"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation."],"pmcid":["PMC3324673"],"funding_grant_id":["R01 AI072543","U19 AI090970","R01 AI072543-04","S10 RR027366","R01 AI072543-03","U19 AI090970-01","R01 AI072543-05"],"pubmed_authors":["Haddad EK","Davidson T","Crotty S","Kroenke MA","Eto D","Locci M","Cho M"],"additional_accession":[]},"is_claimable":false,"name":"Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation.","description":"Follicular helper CD4 T (Tfh) cells provide B cells with signals that are important for the generation of high-affinity Abs and immunological memory and, therefore, are critical for the protective immunity elicited by most human vaccines. Transcriptional regulators of human Tfh cell differentiation are poorly understood. In this article, we demonstrate that Bcl6 controls specific gene modules for human Tfh cell differentiation. The introduction of Bcl6 expression in primary human CD4 T cells resulted in the regulation of a core set of migration genes that enable trafficking to germinal centers: CXCR4, CXCR5, CCR7, and EBI2. Bcl6 expression also induced a module of protein expression critical for T-B interactions, including SAP, CD40L, PD-1, ICOS, and CXCL13. This constitutes direct evidenc","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Apr","modification":"2025-04-04T09:12:58.493Z","creation":"2019-03-27T00:52:13Z"},"accession":"S-EPMC3324673","cross_references":{"pubmed":["22427637"],"doi":["10.4049/jimmunol.1103246"]}}