{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["54(1)"],"submitter":["Emery VC"],"pubmed_abstract":["<h4>Background</h4>The impact of different cytomegalovirus (HCMV) glycoprotein B (gB) genotypes on pathogenesis remains controversial.<h4>Objectives</h4>To investigate the effect of gB genotypes either as single infections or as part of multiple infections on the early kinetics of response to ganciclovir therapy.<h4>Methods</h4>Patients (n=239) enrolled in a study of intravenous ganciclovir or valganciclovir for the treatment of HCMV disease were analysed by a gB genotype specific PCR to quantify the amount of each gB genotype present at initiation of therapy (baseline, day 0) and at days 3, 7, 14 and 21 post therapy.<h4>Results and conclusions</h4>In all gB groups (individual gB genotype infections and mixed genotype infections) there was a biphasic decline in viral load after therapy. Th"],"journal":["Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology"],"pagination":["56-60"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3328767"],"repository":["biostudies-literature"],"pubmed_title":["Differential decay kinetics of human cytomegalovirus glycoprotein B genotypes following antiviral chemotherapy."],"pmcid":["PMC3328767"],"pubmed_authors":["Kumar D","Asberg A","Preiksaitis JK","Rollag H","Emery VC","Humar A","Pescovitz MD","Jardine AG","Hartmann A","Pang X","Gahlemann CG","Manuel O"],"additional_accession":[]},"is_claimable":false,"name":"Differential decay kinetics of human cytomegalovirus glycoprotein B genotypes following antiviral chemotherapy.","description":"<h4>Background</h4>The impact of different cytomegalovirus (HCMV) glycoprotein B (gB) genotypes on pathogenesis remains controversial.<h4>Objectives</h4>To investigate the effect of gB genotypes either as single infections or as part of multiple infections on the early kinetics of response to ganciclovir therapy.<h4>Methods</h4>Patients (n=239) enrolled in a study of intravenous ganciclovir or valganciclovir for the treatment of HCMV disease were analysed by a gB genotype specific PCR to quantify the amount of each gB genotype present at initiation of therapy (baseline, day 0) and at days 3, 7, 14 and 21 post therapy.<h4>Results and conclusions</h4>In all gB groups (individual gB genotype infections and mixed genotype infections) there was a biphasic decline in viral load after therapy. Th","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 May","modification":"2025-04-18T14:46:42.518Z","creation":"2019-03-27T00:52:26Z"},"accession":"S-EPMC3328767","cross_references":{"pubmed":["22410132"],"doi":["10.1016/j.jcv.2012.01.015"]}}