biostudies-literatureUnknown54(1)Emery VC<h4>Background</h4>The impact of different cytomegalovirus (HCMV) glycoprotein B (gB) genotypes on pathogenesis remains controversial.<h4>Objectives</h4>To investigate the effect of gB genotypes either as single infections or as part of multiple infections on the early kinetics of response to ganciclovir therapy.<h4>Methods</h4>Patients (n=239) enrolled in a study of intravenous ganciclovir or valganciclovir for the treatment of HCMV disease were analysed by a gB genotype specific PCR to quantify the amount of each gB genotype present at initiation of therapy (baseline, day 0) and at days 3, 7, 14 and 21 post therapy.<h4>Results and conclusions</h4>In all gB groups (individual gB genotype infections and mixed genotype infections) there was a biphasic decline in viral load after therapy. ThJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology56-60https://www.ebi.ac.uk/biostudies/studies/S-EPMC3328767biostudies-literatureDifferential decay kinetics of human cytomegalovirus glycoprotein B genotypes following antiviral chemotherapy.PMC3328767Kumar DAsberg APreiksaitis JKRollag HEmery VCHumar APescovitz MDJardine AGHartmann APang XGahlemann CGManuel OfalseDifferential decay kinetics of human cytomegalovirus glycoprotein B genotypes following antiviral chemotherapy.<h4>Background</h4>The impact of different cytomegalovirus (HCMV) glycoprotein B (gB) genotypes on pathogenesis remains controversial.<h4>Objectives</h4>To investigate the effect of gB genotypes either as single infections or as part of multiple infections on the early kinetics of response to ganciclovir therapy.<h4>Methods</h4>Patients (n=239) enrolled in a study of intravenous ganciclovir or valganciclovir for the treatment of HCMV disease were analysed by a gB genotype specific PCR to quantify the amount of each gB genotype present at initiation of therapy (baseline, day 0) and at days 3, 7, 14 and 21 post therapy.<h4>Results and conclusions</h4>In all gB groups (individual gB genotype infections and mixed genotype infections) there was a biphasic decline in viral load after therapy. Th2012-01-01T00:00:00Z2012 May2025-04-18T14:46:42.518Z2019-03-27T00:52:26ZS-EPMC33287672241013210.1016/j.jcv.2012.01.015