biostudies-literatureDeshmukh HAMedical Research CouncilNational Institute for Health Research (NIHR)European Commission FP71000-1011https://www.ebi.ac.uk/biostudies/studies/S-EPMC3329377biostudies-literatureUnknown53(5)We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; n = 895), and the observational phase of ASCOT (n = 651), all of whom were prescribed atorvastatin 10 mg. Following genome-wide imputation, we combined data from the three studies in a meta-analysis. We found associations of LDL-c response to atorvastatin that reached genome-wide significance at rs10455872 (P = 6.13 × 10(-9)) within the LPA gene and at two single nucleotide polymorphisms (SNP) within the APOE region (rs445925; P = 2.22 × 10(-16) and rs4420638; P = 1.01 × 10(-11)) that are proxies for the ε2 and ε4 variants, respectively, in APOE. The novel assJournal of lipid researchGenome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a).PMC3329377FP7_223004G9521010NF-SI-0508-10116Ford INeil AHyde CPoulter NStanton AVDurrington PNHitman GABetteridge DJJukema JWChatterjee AJohnson TDeMicco DACharlton-Menys VSever PCaulfield MDeshmukh HAFuller JHPostmus ILivingstone SMcKeigue PMShields DCColhoun HMCalle RATrompet SfalseGenome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a).We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; n = 895), and the observational phase of ASCOT (n = 651), all of whom were prescribed atorvastatin 10 mg. Following genome-wide imputation, we combined data from the three studies in a meta-analysis. We found associations of LDL-c response to atorvastatin that reached genome-wide significance at rs10455872 (P = 6.13 × 10(-9)) within the LPA gene and at two single nucleotide polymorphisms (SNP) within the APOE region (rs445925; P = 2.22 × 10(-16) and rs4420638; P = 1.01 × 10(-11)) that are proxies for the ε2 and ε4 variants, respectively, in APOE. The novel ass2012-01-01T00:00:00Z2012 May2025-04-18T14:46:39.403Z2019-03-27T00:52:27ZS-EPMC33293772236828110.1194/jlr.P021113